| Pumping Iron Store

Laxogenin: A Natural Anabolic for Lean Muscle Gains

Laxogenin is a plant-derived (100% natural) supplement that offers a safe and non-liver-toxic method of gaining muscle mass as well as many all-round benefits to your health and wellbeing. Some of the notable benefits include building lean muscle, promoting fat loss, lowering cortisol levels and enhancing physical performance and recovery.

5 Alpha Hydroxy Laxogenin commonly referred to as “laxo” for short, has been shown to enhance protein synthesis by over 200%! It is structurally similar to ecdysterone, first discovered in Russia. Research has shown that Laxogenin exhibits similar anabolic properties to anabolic steroids such as Anavar; one of the most popular oral anabolic steroids of all time. However, unlike Anavar, Laxogenin exerts its effects without impacting your own body’s hormone levels meaning there is no suppression of testosterone or associated side effects seen with steroid use.

Build lean muscle mass
Promote fat loss
Enhance physical performance
Optimise recovery
Lowers the stress hormone cortisol (which causes fat storage and muscle breakdown)

Is Laxogenin Suppressive?

Laxogenin belongs to a category of plant hormones called brassinosteroids which have a similar structure to animal steroid hormones. However, plant steroids function through a completely different pathway than human steroid hormones and therefore doesn’t affect the endocrine system. It does not convert to the male sex hormones testosterone and dihydrotestosterone, nor does it convert to estrogen so you won’t need to worry about any adverse effects such as gynecomastia.

This is the highlight – this compound is completely safe for both men and women alike. The ideal supplement of choice for anyone seeking to avoid negative side effects.

Natural Muscle Building with Laxogenin

Laxogenin was first discovered in plants, from the same family that includes mustard leaves – in that form, it’s almost one of your five a day! It has some of the same properties as Anavar (or Oxandrolone), one of the most popular oral anabolic steroids of all time.

At the moment Laxogenin isn’t mainstream. That’s because most of the research that’s been done has been in the old school USSR. Word gets out though, maybe through weightlifters from back in the day – and those guys knew what they were doing.

Plant brassinosteroids and their synthetic derivatives may offer a novel therapeutic strategy for promoting growth, repair, and maintenance of skeletal muscles.

Benefits of Laxogenin

Accelerated recovery
Reduction in post-workout muscle soreness
Powerful anti-inflammatory effects; helps with joint pains
Massive pumps and vascularity
Faster gains in strength
Improved resistance to physical and mental fatigue
Safe for both men and women
100% Natural
Doesn’t affect your hormones like testosterone and estrogen
Safe for women
It acts quickly and combines well with protein supplements
Fast-acting – ideal for anyone looking to build muscle and strength quickly
Can be stacked with pretty much any other compound
Can be used for PCT (post cycle therapy) particularly after a prohormone cycle

Supports Fat Loss

The key to what Laxogenin does isn’t totally clear, but what seems to happen is it knocks back production of cortisol, which is a stress hormone – if your cortisol levels are up you can’t grow or produce muscle. With the brakes on the cortisol, your muscles have more chance to bulk up to support your strength. One great side effect is it makes it hard to gain fat, too.

Get the Most of Your Cycle

Laxogenin can be used in many different ways to optimise results whether you’re on-cycle, off-cycle or running a PCT. Its main advantages are:

Stacks well with SARMs and prohormones as it doesn’t affect testosterone and estrogen
It’s a great alternative to prohormones if you prefer zero suppression
An excellent choice to add to your PCT (post cycle therapy)

Thanks to Laxogenin not messing about with your hormones, you can use it long term without hassle. We’ve seen a growing number of people use it for up to 4 months with great results building muscle, reducing body fat, boosting performance and easing mental fatigue.

Mutagenic Labz Metamorphosiz combines Laxogenin (25mg) with Epicatechin 150mg – take 2 capsules per day for best results. Take it with food for better absorption.

Cardarine GW-501516: A Complete Guide to GW501516

05/07/201912/05/2022

In Fat Loss, SARMs, Supplementsby Nicola Joyce

Cardarine GW-501516: A Helpful Guide 2019

In this article, we’ll cover everything you need to know about the PPAR-delta activator Cardarine (GW-501516), how long it takes to work, the ideal cycle length, safety and vital information you need before you consider adding it to your supplement regime.

A lot of the compounds we write about at PumpingIron.com are SARMs (selective androgen receptor modulators). This article is about something a little different, although often classed into the same category. GW501516 can help burn fat, boost metabolism, increase training endurance and protect muscle tissue but it isn’t actually a SARM. It’s a non-hormonal PPAR-delta activator which doesn’t work on the androgen capacitors at all.

If you’re curious about Cardarine, here’s everything you need to know and if we haven’t covered something, simply e-mail us and we’ll be happy to answer your questions!

Is Cardarine (GW-501516) a SARM?

As we said, Cardarine isn’t actually a SARM (anyone who tells you it is doesn’t know what they’re talking about). A SARM activates androgen receptors in muscles and other tissue. Cardarine is a PPAR-delta activator but it can produce results similar to those of SARMs.

Background Information

The best way to understand what to expect from a compound is to look at why it was developed (and what was discovered by researchers). GW501516 was originally developed by a drug company in the 1990s as a way to prevent tumours (especially on the colon and prostate). But there were some surprising discoveries.

During their studies into increased endurance and fat burning, the researchers began to understand more about the PPAR-delta pathway. They realised that activation of this pathway had an astounding impact on muscle growth, endurance and energy whilst decreasing blood lipids and subcutaneous fat. And – you guessed it – the compound GW-501516 can bind to this PPAR-delta pathway.

It turned out Cardarine could help reduce body fat, boost metabolic rate, improve the strength of blood vessels. This has a positive impact on cardiovascular health, increases muscle growth rate and even reduces recovery time. We’ll go into these factors in greater depth later in this article.

One thing we need to make clear: Cardarine is not currently sold for human consumption. It is classed as a ‘research compound’, sold for research purposes only.

How Long Does Cardarine Take to Work?

It’s important to understand how the Cardarine works in the body. Like we’ve already said, it binds to PPAR-delta in muscle cells and it stimulates certain genes which facilitate the body’s use of energy. Once you know that, you can see how it can boost your metabolic rate, improve physical performance and even help burn more fat (whilst increasing and protecting muscle mass).

You’ll notice the effects almost instantly; timing one of your dosages about thirty minutes before a high-intensity training session is an ideal protocol. The difference in energy, endurance and stamina will be noticeable almost immediately.

Burn Fat & Recover Faster with GW-501516

How exactly does Cardarine burn body fat? It’s not as simple as just torching fat right off your body. It starts with preventing the formation of fatty acids chains which, in turn, stops your body actually storing fat. This means your body needs to tap into your subcutaneous fat stores for energy – just like when you diet. But there’s one big difference to when you burn body fat by dieting. GW-501516 has those sought-after anti-catabolic properties, which means you get leaner without losing valuable muscle tissue.

What about boosting recovery between training sessions? It seems Cardarine can help your muscle fibres (specifically the slow-twitch fibres) use oxygen more efficiently, and this can help improve rates of recovery between training. It can also mean better endurance during training sessions. Good news if you train for hypertrophy, with a lower-load and higher-rep style of training.

Cardarine & Bodybuilding

You can already guess that this is an attractive compound for bodybuilders with its potential for muscle gain, training recovery and fat burning. (Side note: it’s also getting a lot of interest with the nootropics crowd.)

Cardarine could be used by itself or with other compounds as a cycle; you can stack it with prohormones, SARMs or other fat-burners. You can also use it to bridge between cycles or throughout a PCT (post cycle therapy) phase. Either way, it should be cycled for best results. Plan your cycle length for 8-12 weeks before having a 4-8 week break.

GW501516 has a half-life of 12-24 hours so you can decide whether to split your dose or to take it once per day. A dosage of 10mg-20mg per day is recommended.

Stacking Cardarine with Other Compounds

Cardarine can be used as a standalone supplement but is often stacked with other compounds. Most commonly, it has great synergistic effects with MK-677, RAD-140, Ostarine, LGD-3303 and Andarine.

It can also be used to combat negative side-effects of some anabolics (such as Trenbolone) and address potential lipid health issues. Cardarine is beneficial during PCT because it can lessen your chances of a fat-regain or rebound after running a steroid or prohormone cycle.

7 Things You Need To Know About Cardarine

#1 Fat Burner

It boosts your body’s fat-burning capacity by stimulating glucose and activating the ABCA1 and CPT1 fat-burning genes. Interestingly, there was a human study done on Cardarine’s potential for receding fatty acids, VLDL proteins and triglycerides (human studies on Cardarine are pretty rare, so it’s worth a look at this one).

#2 Training Endurance

It can stimulate the body’s glucose uptake, encouraging your body to use glucose as its primary fuel source. This means you get more energised for training and can train harder for longer. Since Cardarine can activate PPAR-delta pathways, it can also improve strength endurance. This 2015 study (on mice) suggests Cardarine can increase the specific muscle fibres associated with peak training performance.

#3 Lean Gains

It is a popular choice for stacking with SARMs and other compounds to protect lean muscle tissue whilst dieting to get shredded. As we’ve said, it can help burn body fat without the problem of losing muscle mass or looking over-dieted and scrawny.

#4 Brain Health

It can have a positive effect on blood vessels (see #5) and this means protection for your brain blood vessels (plus more blood to the brain). You might also like to know PPAR activators are thought to boost nerve cell development of nerve cells.

#5 Cardiovascular Health

It can prevent oxidative damage to blood vessels, helping reduce build-up in the arteries and (most exciting for bodybuilders) increasing your nitric oxide (NO) levels. This could mean Cardarine may reduce inflammation and associated tissue damage – a key factor in recovery and muscle growth during hypertrophy.

#6 Liver & Kidney Health

MCP-1 activity is a key factor in kidney disease and Cardarine can reduce this activity. Additionally, Cardarine acts directly on your liver (a powerhouse for storing fats for fuel in the body), using PPAR-delta activation to use fatty acids for energy. Cardarine could even reduce the body’s production of IL-6 and thereby prohibit insulin resistance.

#7 Muscle fibres

Activating PPAR-delta also means Cardarine can encourage better muscle fibre development. This means increased training endurance and the potential for greater muscle growth.

Choosing & Using Cardarine GW-501516

The bottom line is that Cardarine GW501516 is not currently legal for human consumption so it is sold for research purposes. Not for training, cutting, bulking, or bodybuilding.

You also need to bear in mind that Cardarine is banned for any tested bodybuilding competitions (yes, even trace amounts found accidentally in another product). At the moment, almost all the (limited) research on Cardarine GW501516 is on animals.

Don’t risk wasting your money on cheap, fake dupes!

One of the best selling products Mutagenic Labz Amalgamation combines a blend of GW-501516 and SR-9009, a very effective fat-loss combo. If you’re not keen on Cardarine just yet, Check out Mutagenic Labz Assimilation – our safe, legal and insanely effective GDA (Glucose Disposal Agent) to help you get leaner and build more muscle faster.

Disclaimer: By publishing this post we are not recommending using GW501516. It’s our duty to inform and educate you on all compounds. All of the information we have given here can be corroborated by published scientific reviews and literature. We recommend Mutagenic Labz Assimilation.

The Best Epicatechin Dosage for Bodybuilding (2019)

02/07/201912/05/2022

In Testosterone Boosters, Natural Muscle Building, Supplementsby Kristina Vassilieva

The Best Epicatechin Dosage for Bodybuilding (2019)

Wondering about the best Epicatechin dosage for bodybuilding? In the bodybuilding world, we talk about a lot of chemicals. From SARMs to prohormones, peptides and everything in between. Yet somewhere down the line after all the benefits we nearly always hear the term side effects. Well, not today guys… because epicatechin (also known as epicat) really is one of the good guys. What is it and is it really any good?

What is Epicatechin?

Epicat is a flavonol. This means a naturally occurring phytochemical and organic compound found in plants. Essentially it’s what puts the super in superfood and it won’t surprise you to hear that it’s found in a good number of these from Green to Tea to Dark Chocolate.

What Does Epicat Do?

Don’t let its humble origins fool you, epicat is one serious bioactive. Over the years numerous studies have proved time and time again that Epicatechin can enhance muscle growth and strength as well as improving vascularity, blood flow and stamina.

Other benefits include its ability to boost the production of nitric oxide and increasing the sensitivity of insulin. All of which adds up to promoting muscle growth and burning fat. One study has found that daily supplementation with Epicatechin also increases endurance levels.

One of its most notable features, Epicatechin has powerful antioxidant properties which mean Epicat is a natural collateral leveller and has also been linked to improved brain function and healthier hearts.

How does Epicat Work?

Studies suggest that epicat is a natural myostatin inhibitor. Myostatin is a protein which effectively governs the limits of muscle growth. The magic comes from follistatin which is known to affect the levels of myostatin in the body and research indicates that it increases the body’s follistatin level.
In short, epicat reduces the effectiveness of myostatin and less effective myostatin means more muscle.

Epicatechin Dosage for Bodybuilding

It’s safe to take a decent amount of epicat and studies suggests that the most effective ratio of 2mg per kg. The highest density of naturally concurring epicatechin comes from pure cocoa at 3mg per gram. Obviously, it’s going to be hard to get that sort of levels just by eating chocolate, although it might be nice to try, so supplements are clearly the way to go. From previous trials, users who were taking daily epicatechin dosage between 150-200mg have reported optimum results in terms of general fitness, muscle building and endurance, which suggests that this would be the best epicatechin dosage to aim for.

Does Epicat Really Have No Side Effects?

Despite numerous studies and countless research projects, science has yet to directly link a single negative effect on the use of epicatechin. In fact, if anything the opposite is true. A 2007 Harvard University study demonstrated that it lowered the risk of mortality from Diabetes, Strokes, Cancer and Heart disease by 10%.

Epicat is Safe for Women

One of the best things about epicat is the fact that it’s beneficial for both men and women alike. Unlike so many other muscle-building supplements, it’s not hormone-based and can produce great effects regardless of chromosomes.

In conclusion

Epicatechin is the real deal. However, it is worth noting that results from Epicat won’t quite be on the same level as you’d expect from SARMs but it will certainly give you the edge you’re looking for. An organic bioactive substance that has no known side effects, promotes muscle, improves stamina and blood flow and has even been proven to protect against death itself… what’s not to love? Oh, and did we mention you can get it in chocolate?

Mutagenic Labz Metamorphosiz

The Mutagenic Labz Metamorphosiz is a blend of Epicat and Laxogenin. The product is natural and can be used by both men and women. Metamorphosiz is also a great product to use while on PCT to help keep hard-earned muscle gains as the ingredients have zero interaction with HPTA. See our Guide To PCT for some helpful tips.

100% Natural
Epicatechin (EGCG 98%) 150mg
Laxogenin 25mg
Indole 3 carbinol 75mg
Piperine 5mg
Massive pumps and vascularity
Can be used by both men and women
Best-selling natural muscle builder
Shown to increase in protein synthesis and muscle recovery
Boost strength and muscle mass
Comparable to the effects of prohormones but without impacting your hormones
Powerful anti-inflammatory effects; helps with joint pains
Increases endurance

13/03/201812/05/2022

In Supplementsby Kristina Vassilieva

Fat Burners that Actually Work

When you want to get into the best possible shape, fat burners can give the extra edge you need when everything else is in place. If your diet, training and recovery are refined, adding a little extra something might just be the push that you need. Here we’ll take a look at how these supplements actually work, how to use them effectively and their main benefits.

Fat burners are designed to do precisely what their name suggests – target and mobilise fat cells, to burn fat more rapidly. If you’re carrying more weight than you’d like in the form of fat, these nutritional supplements increase energy expenditure and fat metabolism while impairing the absorption of fat, boosting weight loss and increasing fat oxidation while you exercise. So, let’s take a closer look at how these supplements work for your benefit.

How Do Fat Burners Work?

There are several ingredients in fat burners which will stimulate a hormonal reaction in your body to break down fat and use it as a source of fuel. They cannot work effectively on their own, however; you have to eat a healthy diet designed for bodybuilding so that the fat burner can work to its maximum effect. When you eat for fat loss, you’ll find that these supplements help your body to burn extra calories all day long.

What Are Reasonable Expectations From a Fat Burner?

Although fat burners are scientifically proven to work, it’s important to have a reasonable expectation of what these supplements can achieve. They won’t melt an enormous amount of fat every week. However, you can enhance the rate at which you lose fat. It’s considered safe to lose around 1 to 3 pounds every week. If you lose weight more quickly than this, you run the risk of losing lean muscle mass – disastrous in bodybuilding terms.

Start Out Low

Although fat burners are specifically designed to support your fat loss, taking a larger amount of them won’t give you greater results. Make sure to check out the serving guideline so you can measure out the correct dose for your needs. Start with the lowest dosage on the packaging for a couple of weeks before increasing your serving.

How To Cycle Fat Burners

No fat burner will give results continuously. When you use them over an extended period, your tolerance level will go up and they will stop working as effectively. This is why cycling your fat burner supplement is so important. Use your fat burner for around 4 to 6 weeks and then take a break for a couple of weeks before recommencing taking the supplement at a lower dose.

Optimise Your Training

When you’re using fat burners, make building muscle your priority. You need a training programme which will maximise your fat loss at the same time as minimising the amount of muscle you lose. This will ensure you maintain a healthy body composition while boosting your muscle growth.

Don’t Cut Too Many Calories

Although you should consume fewer calories than you manage to burn, going too low is always a mistake. Restricting your calorie intake won’t lead to predictable weight loss and it certainly isn’t a sustainable or healthy way to shed fat.

Take Care With Stimulants

Some fat burners contain stimulants while others do not. Products which have a high caffeine level will make you feel energetic, but they can disturb your sleep quality and that can lead to higher fat gain. It’s important to choose the right product for you, and if you drink a lot of coffee or take other stimulants, it’s usually best to choose a stimulant-free fat burner.

Our best selling stimulant-based fat burner is Yamamoto® Nutrition Ai-BURN®. This premium quality fat burner is a dietary supplement that assists a calorie-controlled diet for optimal fat loss. Thanks to its plant extracts, the product promotes a stable body weight (Green Tea) and metabolic stimulation, particularly of lipids (Bitter Orange). Moreover, cocoa extract supports metabolism and plays a tonic function.

Stimulant-Free Fat Burners

If stimulants aren’t your thing, there are non-stim options such as the MyoBlox Rubix Fat Burner. Rubix™ works on multiple facets of fat loss to aid in improved metabolism and fat utilisation without caffeine or any other stimulant. It boosts metabolism and regulates insulin levels, suppresses appetite and supports fat loss from multiple pathways.

The Olympus Labs Assassinate is another best-selling non-stimulant fat burner that helps to reduce your appetite, prevents the storage of new fat cells and stimulates your metabolism. Assass1nate also doubles as a glucose disposal agent, which helps you to utilize your food as fuel instead of storing it as fat, especially your carbs. So make sure to take it with your carb-heavy meals.

What are the Best Fat Burners?

There are a number of ingredients found in fat burners, however, SARMs have been found to be some of the most effective compounds for fat loss on the market.

Similarly, PPAR-delta activator Cardarine can boost your body’s fat-burning capacity by stimulating glucose and activating the ABCA1 and CPT1 fat-burning genes, which shows superb results such as this human study on Cardarine’s potential for receding fatty acids, VLDL proteins and triglycerides.

Another highly effective compound often used for shedding the fat is Stenabolic SR-9009. Often categorised as a SARM, Stenabolic is a REV-ERB agonist that shows a considerable boost in fat-loss and endurance.

MK-677 (Nutrobal) is also very effective for fat loss but some may suffer from an increased appetite for the first week or two, so discipline is critical.

Summary

There are many excellent fat burning supplements available to help you achieve your bodybuilding goals, but always make sure to buy from reputable online retailers to ensure that you are getting the high-quality product that you’re paying for.