Chemix Cortibloc Cortisol Blocker by The Guerrilla Chemist is a premium, science-based cortisol manager, blocker and fat burner with proven metabolism boosting support. This product not only helps reduce cortisol levels but aids in relieving stress that makes your body want to retain unwanted fat. Cortibloc contains ultra-potent adaptogens allowing your body to become more resistant to stress-inducing forces.

  • Reduces cortisol levels
  • Aids fat loss
  • Improves adrenal gland function
  • Boosts overall energy
  • Creates better daily mood
  • Fat Burner with proven metabolism boosting support
  • Very powerful ingredient for inhibiting cortisol and insulin-induced weight gain

The science has proven that elevated cortisol levels cause stress on your adrenal system causing fatigue, rapid weight gain, stress and exhaustion. This is why The Guerrilla Chemist formulated his newest, highly potent product, Cortibloc™.

Training hard is a key component in building a dense muscular physique but when the body encounters stress, or when you don’t get adequate rest, the central nervous system (CNS) becomes fatigued. Over time your body will respond to stress and lack of rest by creating fat deposits in response to your hormones being under stress. Cortibloc™ not only helps keep your cortisol levels down but it also helps burn unwanted fat and boosts your metabolism to new levels.

How Does Cortibloc Work?

CortiBloc™ is a one-of-a-kind natural cortisol inhibitor that can help with weight loss and regulate cortisol and blood glucose metabolism. The main ingredient in CortiBloc™ is emodin, an anthraquinone compound isolated mainly from the root and rhizome of polygonum cuspitatum, which acts as an 11βhydroxysteroid dehydrogenase 1(11β-HSD1) inhibitor. This enzyme, located in your liver and fat cells, is responsible for the conversion of cortisone(the inactive glucocorticoid) into cortisol(the active form).

Glucocorticoids like cortisol can have deleterious effects on your body if levels get too high. Research has shown that elevated levels of glucocorticoids like cortisol can inhibit glucose uptake in skeletal muscle and can lead to fat gain, obesity, insulin resistance, hypertension, dyslipidemia and type-2 diabetes. Cortisol, which is produced in your adrenal glands in response to stress, is good in small quantities and at the right time. However, long term elevated levels can have serious health implications, as mentioned earlier. Emodin can stop elevated cortisol levels right at the source. Emodin is a selective inhibitor of 11β-HSD1 only, not 11β-HSD2 which is found in your kidneys. Inhibiting this enzyme can cause major health effects such as sodium/potassium absorption/elimination, the buildup of excess mineralocorticoids, interfere with aldosterone and affect kidney function.

Emodin inhibits 11β-HSD1 by blocking the enzyme site from sending a hydride from NADP to cortisone to produce cortisol. Studies show emodin inhibits the enzyme by up to 46% in adipose tissue (fat cells) which means your body is producing almost half of the cortisol it normally would. This can lead to fat loss, reduction in stress, decreased insulin resistance and increased insulin sensitivity. Emodin also reduced fasting blood glucose levels by 77% after taken orally for 7 days, as well as overall plasma insulin levels by 66% relative to the control. In another study, emodin was shown to reduce appetite and body weight in mice (13.9% reduction in body weight).

As you can see, emodin is a very powerful ingredient for inhibiting cortisol and insulin-induced weight gain. Unfortunately, oral bioavailability is very low. In order to fix this issue, we added a large dose of piperine, commonly known as black pepper extract. In a study combining emodin with piperine showed a marked increase in bioavailability via inhibiting glucuronidation. This is the process where a glucose molecule is attached to emodin to make it more water soluble and easy to expel from the body. By stopping this process, the piperine allows emodin to maximally be absorbed and inhibit the formation of cortisol and help you meet and exceed your weight loss goals. This product can be taken by both men and women and works especially well for high-intensity athletes and fitness competitors.

So what does all this mean?

Cortibloc not only helps keep your cortisol levels down but it also helps burn unwanted fat and boosts your metabolism to new levels. Take on your stress with Cortibloc™ available now from Chemix!

Emodin is a multifaceted ingredient that can help improve blood glucose uptake, increase utilization of fat, and significantly decrease cortisol production by inhibiting the enzyme that converts inactive cortisone to cortisol, 11ß-HSD. Whether you are a competitor trying to lose that last bit of stubborn fat from elevated cortisol levels, or trying to increase glucose and fat metabolism, emodin is the game-changer you have been waiting for. This is an extremely unique ingredient and I am extremely excited to welcome it to the Chemix line.

Clinical Studies

Feng, Ying, et al. “Emodin, a natural product, selectively inhibits 11β‐hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet‐induced obese mice.” British journal of pharmacology 161.1 (2010): 113- 126. Di, Xin, Xin Wang, and Youping Liu. “Effect of piperine on the bioavailability and pharmacokinetics of emodin in rats.” Journal of pharmaceutical and biomedical analysis 115 (2015): 144-149. Wang, Yue-jing, et al. “Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in ob/ob mice.” Acta Pharmacologica Sinica 33.9 (2012): 1195.

Read the studies on the ingredients below:

Emodin, a natural product, selectively inhibits 11b-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice

Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts anti-diabetic effect in mice

Additional information

Weight80 g




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Nutritional Information

Serving Size: 1 capsule
Servings Per Container: 60

Amount Per Serving:
Emodin 95% (std from Polygonum Cuspidatum) 500mg
Bioperine (Black Pepper Fruit Extract) 75mg

Other Ingredients: DR (capsule), Magnesium Sterate, Silicon Dioxide

Directions: As a dietary supplement, take one capsule twice daily. Do not take this product for longer than 4 weeks followed by a minimum 4 week break.


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