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Cardarine Review: Your Guide To GW-501516

Read our Cardarine review to understand what it is and why it seems to be shaking things up in the bodybuilding industry! What exactly is Cardarine and what are the benefits for muscle gain and fat loss?

Cardarine (also known as GW 501516) is a very interesting compound that you might have seen cropping up more and more in the bodybuilding and fitness community recently. It is often referred to as a SARM, mainly because it’s often found in the same category as other SARMs and often stacked alongside them. GW actually a PPAR-delta activator. In this article, we discuss what this means, how GW501516 works and why many bodybuilders are turning to Cardarine to help them gain muscle, lose fat, improve their physique and train harder in the gym.

What is Cardarine GW 501516?

Although some people call Cardarine a SARM, it is not actually a selective androgen receptor modulator. Cardarine is actually a PPAR-delta activator but it works in similar ways to a SARM and that’s why bodybuilders and gym trainees are attracted to it for muscle gain, strength gain and fat loss.

Cardarine was originally developed as a potential medical asset for prevention of tumours but it soon showed other benefits: it could help reduce body fat, control body weight, raise the metabolic rate, increase rates of muscle growth, and boost endurance. No wonder bodybuilders are keen to take a closer look!

Like all drugs of its type, Cardarine is banned by WADA and can not be used in professional sport or in any tested competitions – that includes drug tested bodybuilding contests.

Cardarine Review Alongside Trenbolone

Cardarine pairs well with Trenbolone because it can counteract a lot of the negative side effects such as night sweats, reduced endurance, loss of libido, shortness of breath, increased blood pressure and a poor balance between cholesterol levels (high LDL and low HDL).

Tren severely reduces your cardiovascular potential so using Cardarine alongside a Tren cycle makes a very noticeable improvement. Cardarine improves endurance levels and helps athletes to push further, recover faster and greatly improves their cardiovascular health.

Studies have shown that GW-501516 has a positive impact on the balance between HDL and LDL cholesterol which can offset the negative side effects of Trenbolone.

In one study, Cardarine increased HDL cholesterol and decreased triglycerides, insulin, and LDL cholesterol, which may altogether decrease the risk of heart disease.

A number of studies have also shown that Cardarine helps to lower high blood pressure.

Cardarine Review – Before & After Photos

Cardarine is one of the best compounds when it comes to boosting fat loss and increasing your endurance, energy and stamina. This PPAR modulator has been proven through valid research to have many health benefits but its performance benefits are its top advantages.

When it comes to fat loss, you’ll notice a major difference as well as an increase in vascularity as Cardarine promotes the burning of fat as a source of fuel. You’ll also see dramatically reduced recovery times after working out, and even a boost in your mood.

cardarine before and after
Cardarine 12-week cycle before and after photos
  • Incredible endurance enhancement
  • Dramatically reduced recovery time
  • Works from the first dose
  • Improves your mood
  • Enhances fat loss
  • Ideal for interval/cardio training
  • Stackable with other SARMs
  • Is NOT a stimulant and doesn’t increase heart-rate
  • Can be stacked with any other fat burners for maximum fat-burning potential

Read our blog to see more SARMs Before and After Photos.

How Does Cardarine Work?

Cardarine GW 501516 binds to the PPAR-delta nuclear receptors which are mostly in your muscles and stimulates some of the genes which govern how your body uses energy. By doing these two things, Cardarine can:

  • Help you burn more body fat – by preventing fatty acid chains from being formed, and therefore stopping your body from storing fat, so your system has to use stood fat for energy
  • Preserve existing muscle mass – when you are in an energy deficit and your body is forced to use fat for fuel, Cardarine can also protect muscle mass from catabolism
  • Faster recovery – Cardarine may increase the amount of oxygen which gets to your muscles, helping you recover from training sessions

Cardarine Review for Bodybuilding

1 Fat burning

Cardarine can help you burn more body fat by encouraging your body to use stored fat for fuel, by stimulating glucose, and by activating some of the genes involves in fat burning.

2 Bulking and cutting

Cardarine can be stacked with other SARMs to encourage fat loss, boost training performance, and help you maintain muscle mass when dieting – ideal for cutting and bulking cycles.

3 Brain health

Cardarine can improve blood flow to the brain, protecting brain vessels, boosting the growth of nerve cells, and reducing problematic inflammation.

4 Training endurance

Cardarine stimulates your body’s use of glucose for fuel, which means you can probably train longer and harder. More training = more muscle gain!

5 Muscle growth

Cardarine activates the PPAR-delta which boosts muscle fibres, gives you increased energy and means you can train for longer too.

6 Heart health

Cardarine may have a protective benefit for your blood vessels, reducing oxidative damage and plaque build-up, and increasing your levels of nitric oxide.

How To Dose Cardarine

Cardarine is kind of an all-rounder, you can use it for cutting or bulking cycles. It has a half life of 16 hours, so you will need to split your daily total dose into two doses. Start with 10mg/day (5mg twice per day), ideally with one dose 2-3 hours before you train. Run Cardarine for a maximum of 12 weeks, followed by a 6 week off-cycle break.

Can You Stack Cardarine?

A Cardarine Review wouldn’t be complete without some stack suggestions, so here they are! GW can be stacked with most other compounds. It mitigates fat-gain during bulking cycles, increases fat-loss during cutting cycles, and enhances endurance and performance all-round. Here are the most popular SARMs stacks:

Body-Recomposition Stack

  • Cardarine GW-501516
  • Ligandrol LGD-4033
  • Andarine S-4

Cutting Stack

  • Testolone RAD-140
  • Cardarine GW-501516
  • Stenabolic SR-9009
  • Andarine S-4

Strength Stack

  • Testolone RAD-140
  • Cardarine GW-501516
  • Andarine S-4

Bridging Stack

  • Andarine S-4
  • Ostarine MK-2866
  • Cardarine GW-501516
  • Stenabolic SR-9009

Endurance Stack

  • Cardarine GW-501516
  • Stenabolic SR-9009

Bulking Stack (with minimum fat-gain)

  • Cardarine GW-501516
  • Ostarine MK-2866
  • Ligandrol LGD-4033
  • Testolone RAD-140

Does Cardarine Have Any Side-Effects?

Like any compound, you should be sensible about using Cardarine. This includes looking out for side effects. Cardarine won’t suppress your natural hormone levels. It is always recommended to start off with lower doses and assess response and adaptation. If there is anything we haven’t covered in this Cardarine Review, see our Guide to Cardarine for more information.

Cardarine GW-501516: A Complete Guide to GW501516

Cardarine GW-501516: A Helpful Guide 2019

In this article, we’ll cover everything you need to know about the PPAR-delta activator Cardarine (GW-501516), how long it takes to work, the ideal cycle length, safety and vital information you need before you consider adding it to your supplement regime.

A lot of the compounds we write about at PumpingIron.com are SARMs (selective androgen receptor modulators). This article is about something a little different, although often classed into the same category. GW501516 can help burn fat, boost metabolism, increase training endurance and protect muscle tissue but it isn’t actually a SARM. It’s a non-hormonal PPAR-delta activator which doesn’t work on the androgen capacitors at all.

If you’re curious about Cardarine, here’s everything you need to know and if we haven’t covered something, simply e-mail us and we’ll be happy to answer your questions!

Is Cardarine (GW-501516) a SARM?

As we said, Cardarine isn’t actually a SARM (anyone who tells you it is doesn’t know what they’re talking about). A SARM activates androgen receptors in muscles and other tissue. Cardarine is a PPAR-delta activator but it can produce results similar to those of SARMs.

Background Information

The best way to understand what to expect from a compound is to look at why it was developed (and what was discovered by researchers). GW501516 was originally developed by a drug company in the 1990s as a way to prevent tumours (especially on the colon and prostate). But there were some surprising discoveries.

During their studies into increased endurance and fat burning, the researchers began to understand more about the PPAR-delta pathway. They realised that activation of this pathway had an astounding impact on muscle growth, endurance and energy whilst decreasing blood lipids and subcutaneous fat. And – you guessed it – the compound GW-501516 can bind to this PPAR-delta pathway.

It turned out Cardarine could help reduce body fat, boost metabolic rate, improve the strength of blood vessels. This has a positive impact on cardiovascular health, increases muscle growth rate and even reduces recovery time. We’ll go into these factors in greater depth later in this article.

One thing we need to make clear: Cardarine is not currently sold for human consumption. It is classed as a ‘research compound’, sold for research purposes only.

How Long Does Cardarine Take to Work?

It’s important to understand how the Cardarine works in the body. Like we’ve already said, it binds to PPAR-delta in muscle cells and it stimulates certain genes which facilitate the body’s use of energy. Once you know that, you can see how it can boost your metabolic rate, improve physical performance and even help burn more fat (whilst increasing and protecting muscle mass).

You’ll notice the effects almost instantly; timing one of your dosages about thirty minutes before a high-intensity training session is an ideal protocol. The difference in energy, endurance and stamina will be noticeable almost immediately.

Burn Fat & Recover Faster with GW-501516

How exactly does Cardarine burn body fat? It’s not as simple as just torching fat right off your body. It starts with preventing the formation of fatty acids chains which, in turn, stops your body actually storing fat. This means your body needs to tap into your subcutaneous fat stores for energy – just like when you diet. But there’s one big difference to when you burn body fat by dieting. GW-501516 has those sought-after anti-catabolic properties, which means you get leaner without losing valuable muscle tissue.

What about boosting recovery between training sessions? It seems Cardarine can help your muscle fibres (specifically the slow-twitch fibres) use oxygen more efficiently, and this can help improve rates of recovery between training. It can also mean better endurance during training sessions. Good news if you train for hypertrophy, with a lower-load and higher-rep style of training.

Cardarine & Bodybuilding

You can already guess that this is an attractive compound for bodybuilders with its potential for muscle gain, training recovery and fat burning. (Side note: it’s also getting a lot of interest with the nootropics crowd.)

Cardarine could be used by itself or with other compounds as a cycle; you can stack it with prohormones, SARMs or other fat-burners. You can also use it to bridge between cycles or throughout a PCT (post cycle therapy) phase. Either way, it should be cycled for best results. Plan your cycle length for 8-12 weeks before having a 4-8 week break.

GW501516 has a half-life of 12-24 hours so you can decide whether to split your dose or to take it once per day. A dosage of 10mg-20mg per day is recommended.

Stacking Cardarine with Other Compounds

Cardarine can be used as a standalone supplement but is often stacked with other compounds. Most commonly, it has great synergistic effects with MK-677, RAD-140, Ostarine, LGD-3303 and Andarine.

It can also be used to combat negative side-effects of some anabolics (such as Trenbolone) and address potential lipid health issues. Cardarine is beneficial during PCT because it can lessen your chances of a fat-regain or rebound after running a steroid or prohormone cycle.

7 Things You Need To Know About Cardarine

#1 Fat Burner

It boosts your body’s fat-burning capacity by stimulating glucose and activating the ABCA1 and CPT1 fat-burning genes. Interestingly, there was a human study done on Cardarine’s potential for receding fatty acids, VLDL proteins and triglycerides (human studies on Cardarine are pretty rare, so it’s worth a look at this one).

#2 Training Endurance

It can stimulate the body’s glucose uptake, encouraging your body to use glucose as its primary fuel source. This means you get more energised for training and can train harder for longer. Since Cardarine can activate PPAR-delta pathways, it can also improve strength endurance. This 2015 study (on mice) suggests Cardarine can increase the specific muscle fibres associated with peak training performance.

#3 Lean Gains

It is a popular choice for stacking with SARMs and other compounds to protect lean muscle tissue whilst dieting to get shredded. As we’ve said, it can help burn body fat without the problem of losing muscle mass or looking over-dieted and scrawny.

#4 Brain Health

It can have a positive effect on blood vessels (see #5) and this means protection for your brain blood vessels (plus more blood to the brain). You might also like to know PPAR activators are thought to boost nerve cell development of nerve cells.

#5 Cardiovascular Health

It can prevent oxidative damage to blood vessels, helping reduce build-up in the arteries and (most exciting for bodybuilders) increasing your nitric oxide (NO) levels. This could mean Cardarine may reduce inflammation and associated tissue damage – a key factor in recovery and muscle growth during hypertrophy.

#6 Liver & Kidney Health

MCP-1 activity is a key factor in kidney disease and Cardarine can reduce this activity. Additionally, Cardarine acts directly on your liver (a powerhouse for storing fats for fuel in the body), using PPAR-delta activation to use fatty acids for energy. Cardarine could even reduce the body’s production of IL-6 and thereby prohibit insulin resistance.

#7 Muscle fibres

Activating PPAR-delta also means Cardarine can encourage better muscle fibre development. This means increased training endurance and the potential for greater muscle growth.

Choosing & Using Cardarine GW-501516

The bottom line is that Cardarine GW501516 is not currently legal for human consumption so it is sold for research purposes. Not for training, cutting, bulking, or bodybuilding.

You also need to bear in mind that Cardarine is banned for any tested bodybuilding competitions (yes, even trace amounts found accidentally in another product). At the moment, almost all the (limited) research on Cardarine GW501516 is on animals.

Don’t risk wasting your money on cheap, fake dupes!

One of the best selling products Mutagenic Labz Amalgamation combines a blend of GW-501516 and SR-9009, a very effective fat-loss combo. If you’re not keen on Cardarine just yet, Check out Mutagenic Labz Assimilation – our safe, legal and insanely effective GDA (Glucose Disposal Agent) to help you get leaner and build more muscle faster.

Disclaimer: By publishing this post we are not recommending using GW501516. It’s our duty to inform and educate you on all compounds. All of the information we have given here can be corroborated by published scientific reviews and literature. We recommend Mutagenic Labz Assimilation.

Fat Burners that Actually Work

Fat Burners that Actually Work

When you want to get into the best possible shape, fat burners can give the extra edge you need when everything else is in place. If your diet, training and recovery are refined, adding a little extra something might just be the push that you need. Here we’ll take a look at how these supplements actually work, how to use them effectively and their main benefits.

Fat burners are designed to do precisely what their name suggests – target and mobilise fat cells, to burn fat more rapidly. If you’re carrying more weight than you’d like in the form of fat, these nutritional supplements increase energy expenditure and fat metabolism while impairing the absorption of fat, boosting weight loss and increasing fat oxidation while you exercise. So, let’s take a closer look at how these supplements work for your benefit.

How Do Fat Burners Work?

There are several ingredients in fat burners which will stimulate a hormonal reaction in your body to break down fat and use it as a source of fuel. They cannot work effectively on their own, however; you have to eat a healthy diet designed for bodybuilding so that the fat burner can work to its maximum effect. When you eat for fat loss, you’ll find that these supplements help your body to burn extra calories all day long.

What Are Reasonable Expectations From a Fat Burner?

Although fat burners are scientifically proven to work, it’s important to have a reasonable expectation of what these supplements can achieve. They won’t melt an enormous amount of fat every week. However, you can enhance the rate at which you lose fat. It’s considered safe to lose around 1 to 3 pounds every week. If you lose weight more quickly than this, you run the risk of losing lean muscle mass – disastrous in bodybuilding terms.

Start Out Low

Although fat burners are specifically designed to support your fat loss, taking a larger amount of them won’t give you greater results. Make sure to check out the serving guideline so you can measure out the correct dose for your needs. Start with the lowest dosage on the packaging for a couple of weeks before increasing your serving.

How To Cycle Fat Burners

No fat burner will give results continuously. When you use them over an extended period, your tolerance level will go up and they will stop working as effectively. This is why cycling your fat burner supplement is so important. Use your fat burner for around 4 to 6 weeks and then take a break for a couple of weeks before recommencing taking the supplement at a lower dose.

Optimise Your Training

When you’re using fat burners, make building muscle your priority. You need a training programme which will maximise your fat loss at the same time as minimising the amount of muscle you lose. This will ensure you maintain a healthy body composition while boosting your muscle growth.

Don’t Cut Too Many Calories

Although you should consume fewer calories than you manage to burn, going too low is always a mistake. Restricting your calorie intake won’t lead to predictable weight loss and it certainly isn’t a sustainable or healthy way to shed fat.

Take Care With Stimulants

Some fat burners contain stimulants while others do not. Products which have a high caffeine level will make you feel energetic, but they can disturb your sleep quality and that can lead to higher fat gain. It’s important to choose the right product for you, and if you drink a lot of coffee or take other stimulants, it’s usually best to choose a stimulant-free fat burner.

Our best selling stimulant-based fat burner is Yamamoto® Nutrition Ai-BURN®. This premium quality fat burner is a dietary supplement that assists a calorie-controlled diet for optimal fat loss. Thanks to its plant extracts, the product promotes a stable body weight (Green Tea) and metabolic stimulation, particularly of lipids (Bitter Orange). Moreover, cocoa extract supports metabolism and plays a tonic function.

Stimulant-Free Fat Burners

If stimulants aren’t your thing, there are non-stim options such as the MyoBlox Rubix Fat Burner. Rubix™ works on multiple facets of fat loss to aid in improved metabolism and fat utilisation without caffeine or any other stimulant. It boosts metabolism and regulates insulin levels, suppresses appetite and supports fat loss from multiple pathways.

The Olympus Labs Assassinate is another best-selling non-stimulant fat burner that helps to reduce your appetite, prevents the storage of new fat cells and stimulates your metabolism. Assass1nate also doubles as a glucose disposal agent, which helps you to utilize your food as fuel instead of storing it as fat, especially your carbs. So make sure to take it with your carb-heavy meals.

What are the Best Fat Burners?

There are a number of ingredients found in fat burners, however, SARMs have been found to be some of the most effective compounds for fat loss on the market.

Similarly, PPAR-delta activator Cardarine can boost your body’s fat-burning capacity by stimulating glucose and activating the ABCA1 and CPT1 fat-burning genes, which shows superb results such as this human study on Cardarine’s potential for receding fatty acids, VLDL proteins and triglycerides.

Another highly effective compound often used for shedding the fat is Stenabolic SR-9009. Often categorised as a SARM, Stenabolic is a REV-ERB agonist that shows a considerable boost in fat-loss and endurance.

MK-677 (Nutrobal) is also very effective for fat loss but some may suffer from an increased appetite for the first week or two, so discipline is critical.

Summary

There are many excellent fat burning supplements available to help you achieve your bodybuilding goals, but always make sure to buy from reputable online retailers to ensure that you are getting the high-quality product that you’re paying for.

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