TB-500: Injury Repair and Muscle Growth

TB-500: Injury Repair and Muscle Growth (Updated 2024)

TB-500 (Thymosin Beta-4) is a potent peptide and recovery agent with a tremendous ability to speed up injury repair and recovery, however, its many benefits also include growth of muscle mass and improved performance.

TB-500 is naturally produced in the body, in higher concentration at the site of tissue damage and supports the production of new blood and muscle cells.

It also has incredibly powerful anti-inflammatory effects which can oftentimes offer instant pain relief. Its powerful healing effects have been identified specifically in the tendons, ligaments, muscle, skin, heart and eyes.

Before you read any further you should know that this peptide is banned in almost all competitive sports and events. Also, while it is readily available, Thymosin Beta-4 (also known as TB-500) is sold for research purposes only, not for human consumption.

Benefits of TB-500

TB-500, also known as Thymosin Beta-4, is a synthetic version of a naturally occurring peptide found in almost all human and animal cells. It plays a crucial role in various physiological processes, including tissue repair, wound healing, and inflammation modulation. Here are several reasons why TB-500 is considered beneficial for people:

  • Increases muscle growth
  • Increases endurance and stamina levels
  • Decreases inflammation in joints
  • Promotes hair growth
  • Rapid healing of wounds
  • Repair of tendons and ligaments
  • Improved flexibility of joints
  • Promotes the regeneration of blood vessels
  • Repairs damaged heart tissue following a heart attack
  • Heals ulcers and lesions (including stomach and intestinal ulcers)
  • Protects and restores neurons after brain injury

What is TB-500?

TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4. It has not been used to treat humans in any tangible method but although it is not considered a veterinary-specific drug, it is often used in the treatment of horses and occasionally dogs.

As there’s little research on human trials we can only go on what we’ve heard and data compiled from various veterinary trials. Its properties are similar to those of HGH and results also appear similar.

Users report increased strength, muscle growth, enhanced recovery and relief from chronic and severe pain as well as improved endurance. There are also reports of increased hair growth, better condition hair and even a lessening of grey hair.

How does TB-500 Work?

In simple terms, TB-500 boosts your body’s protein efficiency. This means that the functions of those proteins are dramatically improved. It increases red blood cell production and improves metabolism and essentially supercharges your body’s ability to grow new cells.

Additionally, thanks to its molecular composition TB-500 is remarkably light and can, therefore, race your system finding areas to improve. It is this that makes it particularly good when it comes to targeting inflammation and pain.

How to Use TB-500

TB-500 is taken as any other peptides; you’ll need to reconstitute it before injecting the solution either subcutaneously or intramuscularly. To take SubQ, find an area of fatty tissue, the abdomen is good but avoid the navel vicinity.

Next, simply clean your hands, wipe the area with a sterile swab, pinch the area with your fingers and then inject your prepared syringe. To take intramuscularly, locate an area of muscular tissue, usually one where you are experiencing pain, and jab the syringe deep into the muscle tissue. It can be a difficult and painful process, but the rewards should outweigh the trouble.

TB-500 Dosage

The dosage depends on the purpose you are using it for, and/or the type of injury or damage that you need to treat. A general guideline would be between 4-8mg of TB-500 per week for the initial loading phase of 4 to 6 weeks, followed by 2-6mg every 2 weeks to maintain its effects. The effects wear off within 2-3 weeks of injection.

Loading phase:

      • Duration: 4-6 weeks
      • Dosage: 4-8mg of TB-500 per week
      • Frequency: 2mg per injection, between 2-4 times per week (depending on the total dosage you choose)

Maintenance phase:

    • Duration: as long as you need
    • Dosage: 2-6mg of TB-500 every 2 weeks
    • Frequency: 2mg per injection, between 2-3 times every 2 weeks (depending on the total 2-week dosage you choose)

Side Effects

The most common side-effect that has been reported by bodybuilders who use this peptide is that of lethargy and possible headaches. Some report experiencing a head rush immediately after injecting it, although this shouldn’t last longer than a minute.

We lack a lot of data on TB-500 but we do know that the medical community is divided over whether or not it has been linked to cancer; some say it increased the rate at which cancer cells grow, while others suggest it may actually promote white blood cells with which to fight it.

Combine TB-500 and BPC-157 for Healing Injury and Repair

BPC-157 and TB-500, which both stimulate wound healing via various biological mechanisms, have synergistic effects when used together. Clinically developed to boost maximum recovery as well as healing together with adjustability, joint flexibility, and also protection against injury.

BPC stands for Body Protective Compound, and that is exactly its function. It was originally discovered to be a protective peptide within our gut and to have a healing effect in both our upper and lower GI tract.

It should be understood that BPC 157 is only a small part of the whole BPC protein, but it is essential for its functionality because it is where binding spots for enzymes are located. The structure of this stable gastric pentadecapeptide consists of 15 amino acids, and looks a little something like this: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.[1]

Benefits of BPC-157

Some of the world’s top researchers around the worldare working to determine whether BPC 157 contains life-changing properties.

The list of benefits is growing by the day:

  • Useful adjunct to healing almost anything related to the GI tract
  • Heals mitochondrial damage
  • Accelerated healing of ligaments, bones, and tendons
  • Reduces inflammation in autoimmune conditions like rheumatoid arthritis,
  • Protects endothelium and the formation of scar tissue
  • Improves brain health & mood
  • Blocks long term effects of corticosteroid injections
  • Stabilized production of certain hormones and neurotransmitters (eg. serotonin)
  • Protection of the cardiovascular system
  • Reduced drug-induced damage
  • Better general body repair and wound healing
  • Improved body’s response to allergens and viruses

Researcher Ben Greenfield has written extensively about both of them, featuring them in his new book Boundless.

“I’ve personally used peptides BPC-157 and TB-500 to enhance healing and recovery.

“…BPC-157 also accelerates wound healing and, via interaction with the nitric oxide system, protects endothelial tissue and builds blood vessels”

“…TB-500 can be injected in or near any damaged muscle site and sore or injured joint with surprising healing effects”

The similarities between TB-500 and BPC-157

The main similarities between TB-500 and BPC-157 are as follows:

  • Both research peptides have demonstrated anti-inflammatory properties
  • Both research peptides promote angiogenesis (i.e. the formation of new blood vessels)
  • Some researchers contend that TB-500 and BPC-157 increase blood circulation by different mechanisms, but the end result is the same

The differences between TB-500 and BPC-157

There are some obvious differences between these two research peptides.

  • TB-500 has a systemic effect, which means it works regardless of where the injection is made
  • BPC-157 has a localized effect and must be injected near the site of the injury
  • TB-500 works to distribute actin, whereas BPC-157 is directly responsible for increasing actin production.

Keep in mind that the only way to definitively prove the difference between TB-500 and BPC-157 would be to conduct a large-scale clinical trial in which the same type of injury is being treated.

While this type of research has yet to be conducted, it is clear that BPC-157 and TB-500 do not counteract one another.

If anything, anecdotal evidence shows that they work synergistically to speed up the healing process and further accelerate the rate of recovery.

Recommended Dosage for TB-500 and BPC-157

When it comes to TB-500 vs. BPC-157, researchers should know that these research peptides have no safe or recommended dosage.

However, past studies indicate that researchers have dosed them accordingly in the past:

  • BPC-157: 250 mcg injected intramuscularly, daily – once in the morning on an empty stomach and once again right before bed
  • TB-500: 2-4 mg injected intramuscularly, twice a week in evenly spaced doses (ex. Monday and Thursday)

Cycle length is very individual and can vary depending on the specific requirements of the research subject.

Peptides Dosage Calculator

Check out this useful peptides calculator if you need help with your dosages.

Peptides Dosage Calculator

Injury Repair & Recovery Stack (MK-677, BPC-157, TB-500)

The Injury Repair & Recovery Stack combines three of the best healing compounds on the market; MK-677, BPC-157 and TB-500. These compounds stimulate wound healing via various biological mechanisms and have synergistic effects when used together. Clinically developed to boost maximum recovery as well as healing together with adjustability, joint flexibility, and also protection against injury.

Pumping Iron Injury Repair & Recovery Stack
Pumping Iron Injury Repair & Recovery Stack
Laxogenin: A Natural Anabolic for Lean Muscle Gains

Laxogenin: 100% Natural Anabolic for Lean Muscle Gains

Laxogenin is a plant-derived (100% natural) supplement that offers a safe and non-liver-toxic method of gaining muscle mass as well as many all-round benefits to your health and wellbeing. Some of the notable benefits include building lean muscle, promoting fat loss, lowering cortisol levels and enhancing physical performance and recovery.

5 Alpha Hydroxy Laxogenin commonly referred to as “laxo” for short, has been shown to enhance protein synthesis by over 200%! It is structurally similar to ecdysterone, first discovered in Russia. Research has shown that Laxogenin exhibits similar anabolic properties to anabolic steroids such as Anavar; one of the most popular oral anabolic steroids of all time. However, unlike Anavar, Laxogenin exerts its effects without impacting your own body’s hormone levels meaning there is no suppression of testosterone or associated side effects seen with steroid use.

  • Build lean muscle mass
  • Promote fat loss
  • Enhance physical performance
  • Optimise recovery
  • Lowers the stress hormone cortisol (which causes fat storage and muscle breakdown)

 

Is Laxogenin Suppressive?

Laxogenin belongs to a category of plant hormones called brassinosteroids which have a similar structure to animal steroid hormones. However, plant steroids function through a completely different pathway than human steroid hormones and therefore doesn’t affect the endocrine system. It does not convert to the male sex hormones testosterone and dihydrotestosterone, nor does it convert to estrogen so you won’t need to worry about any adverse effects such as gynecomastia.

This is the highlight – this compound is completely safe for both men and women alike. The ideal supplement of choice for anyone seeking to avoid negative side effects.

Natural Muscle Building with Laxogenin

Laxogenin was first discovered in plants, from the same family that includes mustard leaves – in that form, it’s almost one of your five a day! It has some of the same properties as Anavar (or Oxandrolone), one of the most popular oral anabolic steroids of all time.

At the moment Laxogenin isn’t mainstream. That’s because most of the research that’s been done has been in the old school USSR. Word gets out though, maybe through weightlifters from back in the day – and those guys knew what they were doing.

Plant brassinosteroids and their synthetic derivatives may offer a novel therapeutic strategy for promoting growth, repair, and maintenance of skeletal muscles.

Benefits of Laxogenin

  • Accelerated recovery
  • Reduction in post-workout muscle soreness
  • Powerful anti-inflammatory effects; helps with joint pains
  • Massive pumps and vascularity
  • Faster gains in strength
  • Improved resistance to physical and mental fatigue
  • Safe for both men and women
  • 100% Natural
  • Doesn’t affect your hormones like testosterone and estrogen
  • Safe for women
  • It acts quickly and combines well with protein supplements
  • Fast-acting – ideal for anyone looking to build muscle and strength quickly
  • Can be stacked with pretty much any other compound
  • Can be used for PCT (post cycle therapy) particularly after a prohormone cycle

Supports Fat Loss

The key to what Laxogenin does isn’t totally clear, but what seems to happen is it knocks back production of cortisol, which is a stress hormone – if your cortisol levels are up you can’t grow or produce muscle. With the brakes on the cortisol, your muscles have more chance to bulk up to support your strength. One great side effect is it makes it hard to gain fat, too.

Get the Most of Your Cycle

Laxogenin can be used in many different ways to optimise results whether you’re on-cycle, off-cycle or running a PCT. Its main advantages are:

  • Stacks well with SARMs and prohormones as it doesn’t affect testosterone and estrogen
  • It’s a great alternative to prohormones if you prefer zero suppression
  • An excellent choice to add to your PCT (post cycle therapy)

Thanks to Laxogenin not messing about with your hormones, you can use it long term without hassle. We’ve seen a growing number of people use it for up to 4 months with great results building muscle, reducing body fat, boosting performance and easing mental fatigue.

Mutagenic Labz Metamorphosiz combines Laxogenin (25mg) with Epicatechin 150mg – take 2 capsules per day for best results. Take it with food for better absorption.

5 amazing benefits of ostarine mk-2866

5 Surprising Benefits of Ostarine MK-2866

Discover everything you need to know about the popular SARM Ostarine, also known as MK-2866. Ostarine is one of the most popular SARMs in the bodybuilding and physique world – no surprise once you learn about the potential effects of this research-backed compound.

What Is Ostarine?

If you’ve been around the bodybuilding or physique sport world for even a short while, you’ve probably heard about Ostarine. But what is this compound, why do some people use it, and should you consider it (or should you look for a better alternative)? To begin, it’s worth mentioning that this is widely considered one of the safest anabolic SARMs on the market.

MK-2866 is a SARM (Selective Androgen Receptor Modulator) which is popular with strength, power and physique athletes who are looking for ways to boost muscle mass and strength with fewer or no side effects compared to harsher compounds such as steroids or prohormones. It was originally developed to help treat muscle-wasting conditions, so you can understand why bodybuilders are drawn to it. It preserves lean tissue when conditions would usually lead to catabolism (for example, dieting or high-frequency training).

How Does MK-2866 Work?

Like any SARM, MK-2866 can mimic testosterone (the primary anabolic hormone), stimulates the body’s androgen receptors and boosts the steroid hormone receptors. It can activate stem cells, helping to regenerate and build muscle and bone tissue – exactly what bodybuilders want. For this reason, MK-2866 is thought to have fewer side-effects than anabolic steroids because SARMs do not affect the organs. They are very selective by their very nature, which is the main advantage of any SARM. Of course, this can change if someone stacks Ostarine with an anabolic steroid.

Ostarine is renowned for improving both training performance (strength and power) and physique appearance (through bigger, denser muscle mass). However, its noteworthy advantage is injury repair and recovery; it has an excellent affinity for joint repair in particular.

Muscle Gain & Recovery with MK-2866

One reason many bodybuilders use MK-2866 is for its impact on the IGF-1 gene, as well as muscle cells and cells in connective tissues. Ostarine may stimulate these cells which means faster recovery from training stress. Less time out for recovery (or less soreness during your next training session) means you can train more frequently, achieving a greater workload across the training week. This is likely to result in greater muscle growth from the training stimulus.

In one human study of 120 healthy elderly people, Ostarine significantly increased lean muscle mass as well as fitness levels with no side effects or steroid-like risks.

5 Potential Effects Of Ostarine

There are five key reasons a bodybuilder might choose to use Ostarine.

#1 Muscle gain
The SARM is often used as a compound to aid muscle gain because of its effect on stimulating muscle cells. Not only does this mean you may gain additional muscle tissue but you are likely to protect the muscle mass you already have (important during a fat loss phase).

#2 Recovery
It can mean faster recovery from DOMS and training fatigue. This means you can train more frequently and you can push harder during each session.

#3 Fat loss
It is thought to slow or stop muscle breakdown (catabolism) whilst the body is getting leaner. This means you can push harder during a dieting phase without the usual worry about losing muscle, resulting in the holy grail of lean gains.

#4 Cardiovascular health
Ostarine can have a number of benefits for heart health, including reduction of triglycerides, reduced lipids and reduced total cholesterol. It may also help lower blood glucose levels and improve insulin resistance.

#5 Increased metabolic rate
It is thought to increase base metabolic rate, meaning you will burn more calories during training, NEAT and cardio. It can also increase endurance and give you better stamina, which will also mean longer more intense training sessions. All these combined means you are likely to burn more calories – good news if you are trying to get shredded.

How Long Does MK-2866 Take to Work?

As with most supplements, one of the most commons questions asked is how long MK-2866 takes to work. Anecdotal evidence shows that people tend to feel a great sense of ‘wellbeing’ within 2-3 days of using Ostarine. A sense of vitality, positive mood, good energy and holistic ‘balance’.

Many bodybuilders and athletes report noticeable consistent strength gains within the first 2-3 weeks of using the compound. In terms of physical changes; body composition and muscle definition, results will usually be seen to the eye from 4 weeks onwards, however, it’s important to understand that this ultimately comes down to so many individual factors. Your current body composition, your goals, your training and diet, as well as recovery protocols. Everyone will respond to different compounds in different ways whilst your efforts and commitment will play an even bigger part in how quickly you see results.

Ostarine & Bodybuilding

MK-2866 is best known for is building muscle and burning fat – two things all bodybuilders are interested in at some point during their lifting career (even if they never want to step on stage).

Muscle gain: remember how we said Ostarine was originally developed to help tackle muscle wasting diseases? People who want to build more muscle tissue, and hang on to the muscle they’ve got, can use MK-2866 to harness those anti-catabolic effects.

Fat burning: Ostarine has muscle preserving properties, meaning you can diet more aggressively or for longer without losing muscle tissue. Retaining muscle during a diet phase means you’ll also retain more strength, so you can train harder and heavier, all leading to a positive circle of lean gains.

But there’s more than muscle building and boosted fat-burning abilities. Ostarine can also boost bone health, help reduce LDL and triglycerides and improve insulin resistance. These are all things which can be attractive to bodybuilders looking to gain mass and strength.

How to Stack Ostarine

Bodybuilders use Ostarine in a few different ways. This is what you need to know.

Using Ostrarine by itself: Ostarine MK-2866 can be used alone. It should be used as a cycle (like any SARM) of 12 weeks for men, up to 8 weeks for women. Men should use between 15-25mg and women should use 5-10mg. Ostarine has a half-life of 24 hours so there is no need to split the dose across the day.

With other SARMs: bodybuilders typically stack Ostarine with other popular SARMs, like Ibutamoren MK677 or Ligandrol LGD-4033. Ostarine can also be used in a so-called “triple SARM” stack of Ostarine plus Andarine and Cardarine (although Cardarine isn’t a true SARM).

Choose The Best Ostarine Supplement

Like any SARM, it’s important you choose the best-quality Ostarine MK-2866 supplement. Don’t go for the cheapest product. Check the label carefully and look for smart ingredients which are designed to optimise the product’s effectiveness so you see the best gains.

We love our best selling Mutagenic Labz Ostagainz, which delivers 10mg of pure Ostarine MK-2866 along with Piperine in every dose (to aid digestion and absorption). It’s non-liver-toxic, has no androgenic activity, and promises minimal side effects – with maximum results. Click here to try it for yourself. Choose an Ostarine product you can trust, backed by a reliable name in bodybuilding supplements.

We should point out that Ostarine – like all SARMs – is not approved for use in tested strength and physique sports but for those of you who don’t want to compete with the tested federations? There are so many reasons to try Ostarine by itself or as a stack, whether you’re dieting, bulking, or aiming for a body recomposition phase.

LGD-4033: Amazing Benefits of Ligandrol

LGD-4033: Amazing Benefits of Ligandrol

Hailed as the ‘King of SARMs’, LGD-4033, also known as Ligandrol or LGD for short, is quickly becoming the SARM of choice for bodybuilders, weightlifters, crossfitters and even fitness models. In the bodybuilding world, SARMs are often used as a safer substitute for anabolic steroids. SARMs have many of the advantages of steroids without the nasty side effects but the purpose for taking them both remains the same; to enhance fat loss while building muscle, to improve performance and strength, as well as to promote healing and recovery.

See our guide to Bridging Prohormone Cycles with SARMs.

Dropping fat while you’re trying to increase muscle mass seems counter-intuitive and with good reason. Biology doesn’t like the idea in general, so if you’re trying to achieve this effect you’re going to need some help. Ligandrol is probably the most effective. It’s taken orally and was developed to combat muscle-wasting conditions and osteoporosis.

How Does LGD-4033 Work?

LGD-4033 binds itself to targeted androgen receptors in muscle tissue. It is this selective nature which allows Ligandrol to be taken orally rather than by injection. Because of its selective nature, LGD-4033 naturally avoids major organs which makes it a lot safer than some of the alternatives and especially steroids.

LGD-4033 increases the body’s testosterone levels, which promotes muscle growth, improves the amount of energy produced by the body and generally boosts blood circulation. There has been some suggestion that LGD-4033 also improves bone density which would make sense considering its potential as a treatment for osteoporosis.

The Benefits of Ligandrol

The many benefits of Ligandrol reflect its extremely popular status as one of the best SARMs on the market today:

  • Promotes lean and dry muscle mass gains
  • Sustainable results, even at lower doses
  • Boosts fat loss
  • Increases libido
  • Increases stamina and endurance
  • Promotes recovery
  • Considered the best SARM for bulking amongst many
  • Ideal for body recomposition (losing body fat whilst gaining muscle)
  • Stacks brilliantly with Cardarine for effective cutting cycles
  • Gives amazing pumps and fullness
  • Increases cardiovascular strength by week 3
  • Gives a heightened sense of wellbeing without mood swings or crashes
  • More powerful than Ostarine
  • The closest SARM you can get to testosterone
  • No bloating or water retention
  • No male-pattern hair loss
  • No liver damage
  • No changes in cholesterol or blood pressure

LGD-4033 Increases Libido

SARMs are selective in their nature but they also affect the brain and offer a host of cognitive benefits. This explains their positive effects on libido and mood enhancement. There have been many anecdotal reports supporting that LGD4033 can greatly improve cognition, libido and energy; most users report an increased sense of wellbeing and stamina when using this SARM.

Ligandrol Side-Effects

Ligandrol is still new and there hasn’t been a great deal of research on it. The few studies that do exist suggest the SARM is easily tolerated by the body and few if any side effects have been recorded.

The studies and other anecdotal evidence does suggest that users will experience very slight suppression. In most cases, there is no need for a PCT but some may prefer to run a mild over-the-counter PCT supplement and a Testosterone Booster to optimise natural testosterone levels post-cycle.

LGD-4033 doesn’t increase estrogen levels so there is no risk of man boobs, puffy nipples or water retention.

Although safer than some of the other SARMs on the market and clearly safer than steroids, there is some anecdotal evidence to suggest that Ligandrol can cause headaches and nausea.

Dosage

The few studies that have taken place suggest that doses as low as 1mg per day are enough to have a significant effect on muscle growth and that doses as high as 25mg showed little, to no, side effects.

An entry-level dose of 5mg per day rising to 10mg if you’re on the heavier side. The results that have come in suggesting that a cycle of 2-3 weeks is enough to cause a significant effect but 4-8 weeks is ideal.

How to Take LGD-4033

The half-life of LGD 4033 is 24–36 hours, therefore it can be taken just once per day. Keep in mind is that its long half-life means that the levels of LGD-4033 will gradually build up in your system over the course of your cycle. Studies showed that blood levels nearly tripled after 3 weeks compared to the first day.

While most SARMS are often stacked together for optimum results, a lot of users see great results with LGD-4033 as a standalone. Stacking Ligandrol works best with MK-677, Cardarine, Ostarine and Testolone RAD-140.

In conclusion

LGD-4033 is a potent yet safe SARM that stacks well with other SARMs, prohormones and supplements, and the fact it can be taken orally is a bonus.

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