bodybuilder steroids supplements prohormones pct guide

PCT: Your Best Guide to Post Cycle Therapy (2024)

Post-Cycle Therapy, or PCT for short, is essentially the process of levelling your body’s hormone levels after a SARMs, steroid or prohormone cycle. Simply put, your body may cease to produce or at least lower your natural hormone production when subjected to significantly raised levels of exogenous substances.

To run the most effective PCT, there are 5 goals we want to achieve:

  1. To restart HPTA
  2. Prevent catabolism as our cortisol level rises
  3. Prevent fat gain while retaining enough calories to maintain the muscle
  4. Minimise the loss of strength
  5. To balance our hormones in order to reduce potential negative effects

HPTA Restart Protocol

The HPTA (Hypothalamic-Pituitary-Testicular Axis) restart protocol is a method used to help restore natural hormone production in the body, specifically testosterone, after it has been suppressed due to the use of anabolic steroids or similar substances.

Restarting the HPTA has been covered many times, a quick evolutionary search on SERMs and you will find many articles relating to the use of both Clomid and Nolvadex, these can be combined together or used solo. To restart HPTA Clomid is a solid choice but you can also use Nolvadex. Both are effective in aiding recovery.

Here’s a simple breakdown:

  1. Hypothalamus and Pituitary Gland: These are parts of the brain that control the production of hormones. When you take steroids, your body senses the extra hormones and signals the hypothalamus and pituitary gland to stop producing certain hormones, including testosterone.
  2. Testicular Function: Testosterone is primarily produced in the testes (testicles). When external hormones are introduced (such as steroids), the testes can stop making testosterone because they’re getting enough from outside sources.
  3. Restart Protocol: The HPTA restart protocol aims to kickstart the natural production of testosterone in the body by using certain medications or supplements. This typically involves taking substances that mimic the action of natural hormones or that stimulate the production of hormones in the hypothalamus and pituitary gland.
  4. Timeline and Monitoring: The protocol usually involves a specific timeline of taking these medications or supplements, along with regular monitoring of hormone levels to ensure that natural production is being restored effectively.

Overall, the HPTA restart protocol is a way to help the body recover its natural hormone production after it has been disrupted by the use of steroids or similar substances.

When should I Start PCT?

The timing of PCT can vary depending on the specific compound and cycle length. As a general rule, it’s best to wait until the exogenous compounds have cleared your system before starting PCT. This can range from  1 day to several days, depending on the compound and dosage used. It’s important to do research on the specific compound you’re using. For SARMs and prohormones, you can start PCT after 24 hours since your last dosage.

How Long Should PCT Last?

The duration of post cycle therapy (PCT) can vary depending on factors such as the specific compounds used, the duration and intensity of the cycle, and individual response to the substances.

A common timeframe for PCT is around 4 weeks, but it may need to be extended if recovery is slow or if more aggressive compounds were used during the cycle.

It’s important to follow a PCT protocol recommended by a knowledgeable healthcare professional or experienced user to ensure proper recovery and hormone balance.

Do I Need to do PCT if I Use Natural Supplements?

No. PCT is typically only necessary if you use exogenous compounds such as steroids or SARMs that can impact your body’s natural testosterone production. If you’re using natural supplements, such as Epicatechin or Laxogenin, you won’t need to do PCT.

Ostarine Prevents Catabolism During PCT

At this transition point, your body will quickly begin to produce testosterone. It’s here you must be careful not to allow excess cortisol from chewing up your hard-earned muscle. At the same time, your body will have little to no nitrogen which will cause your muscles to crave nutrients that you don’t have.

To counter these effects, prevent catabolism and lessen the amount of muscle loss, a sensible solution is to introduce a non-suppressive anabolic; and this is the greatest opportunity for SARMs to really shine. A low dose at 10mg of Ostarine (MK-2866) will help preserve your muscle gain and increase your nitrogen and IGF levels. This will also help you continue smashing your workouts and even improve muscle pumps.

Cardarine Prevents Fat Gain During PCT

After you’ve dealt with your cortisol levels, you’ll find that the excess testosterone binds with it, rendering it inactive. To prevent fat gain yet keeping your calories up requires a PPAR modulator such as Cardarine (GW-50156). This will regulate the rate at which you burn fat. It does this in a number of ways but essentially it promotes glycogen retention in muscle tissue. This allows the body to alter its metabolism and increase the amount of fat burned instead of using carbs or protein as fuel.

This is a true win/win and means your body retains muscles and yet fat retention is reduced. This, in turn, will give you more stamina and can have the added bonus of reducing cravings.

Balancing Your Hormones During PCT

The drawback to most PCT is the potentially negative side effects. To counter these you need to ensure you keep your hormones balanced. As testosterone levels rise, estrogen levels are also significantly increased and sometimes at a faster rate. Estrogen flooding causes skin problems and can even cause gynecomastia (swelling of the nipples).

To counteract this, Aromasin can be used to inhibit aromatase whilst only increasing your IGF levels by approximately 30%. Aromasin will also prevent estrogen rebound and therefore save you from developing man-boobs. Taken on alternate days, a 12.5mgs dose of Aromasin is great for PCT. It helps up your testosterone levels by actually lowering estrogen.

Benefits of an Aromatase Inhibitor

Although some supplements and SARMs do not convert to estrogen, you will still get the odd one or two guys who experience estrogen-related side effects during their cycle. In such cases, a mild over-the-counter PCT supplement with an aromatase inhibitor is ideal. Mild suppression of testosterone will throw your estrogen levels out of balance and therefore can cause side effects in those who are more prone.

The extent of these side effects will always depend on several factors:

  • Which compound you are using
  • The dose
  • The length of your cycle
  • Your individual predisposition to suppression

For most prohormones and SARMs, your best solution is Arimistane or 6-OXO.

What is 6-OXO?

6-Oxo in Pumping Iron Pro PCT is used to block the conversion of testosterone to estradiol. When the body has more testosterone, the anabolic potential is significantly increased. This will help to build more lean muscle and increase overall body strength.

By having more testosterone, not only will you have increased muscle mass but there is a greater capacity to decrease body fat. Favourable testosterone to estrogen ratio is critical for achieving optimal body composition.

Pumping Iron Pro PCT (6-OXO)
Pumping Iron Pro PCT (6-OXO)


  • 6-OXO is the strongest legal aromatase inhibitor on the market
  • Increases lean muscle mass
  • Reduces conversion of testosterone to estradiol
  • Supports muscle retention
  • Increases testosterone:estrogen ratio

What is Arimistane?

Arimistane is a powerful Aromatase Inhibitor (AI) and cortisol blocker that effectively reduces circulating levels of estrogen in the body. It acts as a suicide inhibitor to decrease the number of androgens in the body that can change to estrogen.

Arimistane is a great compound to use for PCT after a prohormone cycle as it increases testosterone whilst lowering estrogen levels. This also means it’s an effective natural muscle builder so you can expect a noticeable increase in muscle growth, strength, muscle hardness and definition.

Enhanced Athlete Arim-RX
Enhanced Athlete Arim-RX


  • Blocks high levels of estrogen and cortisol
  • Increases testosterone levels
  • Increases muscle mass
  • Reduces fat storage
  • Improves recovery
  • Improves vascularity
  • Drying and muscle hardening effect
  • Boosts libido

What is Blue Ox?

Enhanced Labs Blue Ox is a natural test booster supplement for men that supports a balanced mood and optimal strength. Blue Ox is often stacked alongside more potent PCT compounds.

Whether you’re off-cycle or just pure natty, our Blue Ox booster is chock-full of essential ingredients that excel in boosting virility and libido.

  • 120 Capsules
  • PCT Regeneration
  • Boost strength and muscle
  • Maintain muscle mass between cycles
  • Increase libido and sexual performance
  • Support healthy energy levels
  • Mood support


Enhanced Athlete Blue Ox Test Booster
Enhanced Athlete Blue Ox Test Booster


  • Clinically formulated to naturally elevate testosterone levels
  • Contains 9 naturally derived pharmaceutical grade ingredients to increase the body’s own natural testosterone production through multiple different pathways
  • Contains natural anti-estrogen ingredients to regulate estrogen production and remove the metabolites that can cause health concerns like water retention and gynecomastia
  • All of the ingredients in Blue OX have been scientifically verified in human studies

How to do a SARMs PCT

PCT protocol is a highly debated and subjective matter depending on the individual so we can’t advise you on what you should/shouldn’t do but we can give you some guidance. In general, a person cannot be sure which option is best for them unless they do blood tests before and post cycle. Every individual is different and the many factors that will affect your requirements include:

  • Your starting point/baseline
  • Any previous supplement/cycle history
  • Your predisposition/genetics
  • Your age
  • Which compound(s) you are using
  • The dosage(s)
  • The length of your cycle
  • How your body reacts to the compound(s)
  • Side effects encountered – if any

There are some options you can look at:

  1. Aromatase Inhibitor: Suitable for Ostarine and (for some people) potentially other SARMs (such as LGD-4033, LGD-3303, S-4), and/or shorter cycles up to 8 weeks): A mild over-the-counter PCT stack that includes an aromatase inhibitor (Arimistane) such as Arim-RX combined with a high-quality natural testosterone booster such as Blue Ox.
  2. SERMs: For potent compounds (such as RAD-140, YK-11, S-23), advanced stacks and long cycles: A full PCT which includes a SERM (selective estrogen receptor modulator, not to be confused with SARMs), such as Nolvadex and Clomid.
  3. 6-OXO – A very potent aromatase inhibitor that is effective for most people and most compounds including prohormones and SARMs, often combined with a natural testosterone booster such as Blue Ox.

A SERMs PCT protocol for an advanced cycle may look like:

  • Nolvadex (Weeks 1-4): 40mg/40mg/20mg/20mg
  • or Clomid (Weeks 1-4): 50mg/50mg/25mg/25mg

Preparation is key. One thing we can recommend is always having both options on hand in case you find that you need to run a full PCT, even if you haven’t anticipated this possibility.

A proper PCT is equally as important as your cycle. Don’t wait until near the end of your cycle to find the products that you need.

You can also make a judgement on the signs of testosterone suppression if you experience any of these (low energy, low libido, sadness, loss of strength and motivation, chronically poor performance in the gym) after finishing the cycle which will give you an idea of how suppressed you are. This also applies after you complete your PCT to assess the indicators of a successful PCT. Always ensure to take enough time off between cycles to ensure adequate recovery; listen to your body and if in doubt, take more time off.

Read more about Bridging Prohormone Cycles with SARMs to get the most out of your PCT protocol.

Bridging with SARMs

Bridging with SARMs (3 Best Compounds)

One of the biggest challenges you’ll face after a steroid or prohormone cycle is keeping the gains and that’s where bridging with SARMs is a game-changer. It’s the fear of losing gains that encourages the poor habit of staying ‘on-cycle’ for extended periods of time. Clearly, this is not ideal since it can seriously damage your health and organs; our bodies aren’t designed to take that kind of strain. So how can you deal with ‘off-cycle’ blues?

The answer is bridging with SARMs. Simply put, SARMs are built for this.

What is Bridging with SARMs?

If you are not familiar with bridging, this is the phase of recovery or ‘time-off’ between steroid or prohormone cycles. As some of you will know, it is the time you’re desperately fighting to maintain the same strength, power and endurance as you had during your cycle. This is the time you try to maintain the gains that you’ve worked so hard for.

As a general guideline, the minimum time-off should be the total time on-cycle plus the length of the PCT. For example a 12-week cycle with 4 weeks PCT is a 16-week cycle in total. This would reflect the duration of 16 weeks off, after the PCT.

Inevitably, this is a time when you will lose some strength and you will experience a dip in energy, which can cause physical and mental strain.

Don’t despair. This is a time when SARMs truly shine.

This is where “bridging” comes into play. For athletes on SARMs, a perfect bridge is one that allows one to maintain a huge majority of gains whilst helping to restore hormonal balance.

Benefits of Bridging with SARMs

SARMs still don’t get the credit they deserve in the bodybuilding community but good quality SARMs, at the right dose, can provide the perfect bridge when taking time off. Although there is some confusion, SARMs are not anabolics and some can benefit your recovery phase, providing the dosage is low.

SARMs like Ostarine and Andarine were designed specifically to prevent muscle loss and lend themselves perfectly to that function. Not only that, but used at a low dose they can give the impression of still being ‘on-cycle’ and can help firm up your neural drive. Physiologically, they increase anabolic activity and thus will not only prevent muscle loss but also aid recovery.

Top 3 SARMS for Bridging

#1 Ostarine (MK-2866)

Ostarine prevents catabolism during your bridging phase, and also improves insulin resistance and lowers blood glucose levels.

At this transitioning point, your body will begin to produce testosterone but you must be careful not to allow excess cortisol from chewing up your hard-earned muscle. At the same time, your body will have little to no nitrogen which will cause your muscles to crave nutrients that you don’t have.

To counter these effects, prevent catabolism and lessen the amount of muscle loss, a low dose Ostarine helps to preserve your muscle mass and increase your nitrogen and IGF levels. This will also help you continue smashing your workouts and even improve muscle pumps.

#2 AC-262

AC-262 is designed to selectively target androgen receptors in muscle and bone tissues while minimizing effects on other organs. This selectivity is intended to provide anabolic benefits with reduced androgenic side effects.

Compared to stronger SARMs, AC-262 is thought to have milder androgenic effects, potentially minimizing side effects such as hair loss and prostate enlargement.

Research studies have shown an increase in fat burning, performance and endurance levels. AC- 262 SARMs studies have suggested suggest could be a future treatment of Alzheimer’s disease.

#3 Andarine (S-4)

Andarine is one of the most researched SARMs, often used for bridging because it is very minimally suppressive. Andarine has shown the most favourable ratio of anabolic/androgenic effects. This means more gains and fewer unwanted side-effects. This is also why it makes a fantastic SARM for women.

This dry compound yields superb results famed for the hard, chiselled look. It not only increased muscle mass and calcium production for increased bone density but it did so in a highly selective manner. When applied to humans, this means it is able to selectively stimulate anabolic activity, allowing the user to mostly surpass any of the nasty side effects associated with products of similar potency.

The Best SARMs for Maintaining Mass Between Cycles

The 3 best SARMs for maintaining muscle mass between cycles are: AC-262, S-4 or Ostarine.

Considered the mildest SARMs with minimal test suppression, they are sometimes considered for bridging for the following reasons:

  1. Muscle Preservation:
    • One of the goals during the bridging period is to preserve the muscle gains achieved during the previous steroid cycle. AC-262 and Ostarine are believed to have anabolic properties that can help in maintaining muscle mass, making them potential candidates for this purpose.
  2. Lower Androgenic Effects:
    • SARMs are designed to be selective in their action, targeting androgen receptors in muscle and bone tissues while minimizing effects on other organs. This selectivity may result in fewer androgenic side effects.
  3. Hormonal Balance:
    • AC-262 and Ostarine are thought to have a more favorable impact on hormonal balance compared to other stronger compounds. This may be particularly relevant during the bridging phase when users aim to allow their endogenous testosterone production to recover.
  4. Reduced Suppression:
    • While SARMs can still suppress natural testosterone production, the degree of suppression is generally considered to be milder than that seen with anabolic steroids. This is an important factor during the bridging phase, as minimizing suppression allows for a quicker return to natural hormonal levels.

Reducing Fat Gain Between Cycles

Cardarine (GW-501516)

Although not a SARM, it’s often found in the same category. Cardarine prevents fat gain. After you’ve dealt with your cortisol levels, you’ll find that the excess testosterone binds with it, rendering it inactive.

To prevent fat gain yet keeping your calories up requires a PPAR modulator such as Cardarine (GW-50156). This will regulate the rate at which you burn fat. It does this in a number of ways but essentially it promotes glycogen retention in muscle tissue. This allows the body to alter its metabolism and increase the amount of fat burned instead of using carbs or protein as fuel.

This is a true win/win and means your body retains muscles and yet fat retention is reduced. This, in turn, will give you more stamina and can have the added bonus of reducing cravings.

The 12 Week SARMs Bridge

This is an example of the ideal SARMs bridge, which would follow your prohormone or steroid cycle. Bridging with SARMs would begin immediately after completing your cycle and PCT (i.e. the bridge is going to fill the ‘off-cycle’ period that would usually follow your cycle).

Weeks 1-12 – Ostarine (MK-2866) 10mg per day  (full dose once per day in the AM)
Weeks 1-12 – Cardarine (GW-510516) 20mg per day (full dose 30 minutes before workout)
Weeks 9-12 – Arimistane/DAA

Weeks 13-16 – Mini PCT:
Clomid 50/25/25/25
Cardarine (GW-501516) 20mg per day

Bridging with SARMs Effectively

There are 3 key factors to consider when bridging with SARMs, and each is equally important. It’s not just about the supplements you use; its the foundation you lay and that comes from the following:


You can’t just let yourself go when you move ‘off-cycle’. Your chemistry may be changing, but you can’t allow your focus to slip. Keeping up a solid mental state is essential if you don’t want to lose your gains. Losing your aggression and neural drive can be as damaging as losing muscle gain so it’s important to keep your mind sharp.


You don’t need us to tell you how important diet is to bodybuilding. Indeed some would say it’s the most important aspect of all. It’s essential that when you move ‘off-cycle’ you adjust your diet accordingly. Increasing your protein intake and equalizing your carbohydrate and fat intake will help you keep your muscle mass. There’s no hard and fast rule to this, but just keep in mind that your diet ‘off-cycle’ should not be the same as your ‘on-cycle’ diet.


In order to bridge successfully, it’s important to stay on top of your training. One way to achieve this is to ensure that when you’re ‘on-cycle’ you focus more on lower weight and higher reps, whilst your off-cycle training should be heavy. Heavier training, when you’re off-cycle or bridging, will effectively build strength and help to maintain the muscle mass you build during your cycle.

In conclusion

All of the above factors are important when bridging with SARMs. To get the most of your cycle, as well as your bridge, each phase requires a subtle balance of all factors to optimise progress as well as health. Be prepared and be well-read. Read our Guide to PCT After Prohormone Cycle to ensure you optimise results, health and recovery.

cardarine review photos blog

Cardarine Review: Your Guide To GW-501516

Read our Cardarine review to understand what it is and why it seems to be shaking things up in the bodybuilding industry! What exactly is Cardarine and what are the benefits for muscle gain and fat loss?

Cardarine (also known as GW 501516) is a very interesting compound that you might have seen cropping up more and more in the bodybuilding and fitness community recently. It is often referred to as a SARM, mainly because it’s often found in the same category as other SARMs and often stacked alongside them. GW actually a PPAR-delta activator. In this article, we discuss what this means, how GW501516 works and why many bodybuilders are turning to Cardarine to help them gain muscle, lose fat, improve their physique and train harder in the gym.

What is Cardarine GW 501516?

Although some people call Cardarine a SARM, it is not actually a selective androgen receptor modulator. Cardarine is actually a PPAR-delta activator but it works in similar ways to a SARM and that’s why bodybuilders and gym trainees are attracted to it for muscle gain, strength gain and fat loss.

Cardarine was originally developed as a potential medical asset for prevention of tumours but it soon showed other benefits: it could help reduce body fat, control body weight, raise the metabolic rate, increase rates of muscle growth, and boost endurance. No wonder bodybuilders are keen to take a closer look!

Like all drugs of its type, Cardarine is banned by WADA and can not be used in professional sport or in any tested competitions – that includes drug tested bodybuilding contests.

Cardarine Review Alongside Trenbolone

Cardarine pairs well with Trenbolone because it can counteract a lot of the negative side effects such as night sweats, reduced endurance, loss of libido, shortness of breath, increased blood pressure and a poor balance between cholesterol levels (high LDL and low HDL).

Tren severely reduces your cardiovascular potential so using Cardarine alongside a Tren cycle makes a very noticeable improvement. Cardarine improves endurance levels and helps athletes to push further, recover faster and greatly improves their cardiovascular health.

Studies have shown that GW-501516 has a positive impact on the balance between HDL and LDL cholesterol which can offset the negative side effects of Trenbolone.

In one study, Cardarine increased HDL cholesterol and decreased triglycerides, insulin, and LDL cholesterol, which may altogether decrease the risk of heart disease.

A number of studies have also shown that Cardarine helps to lower high blood pressure.

Cardarine Review – Before & After Photos

Cardarine is one of the best compounds when it comes to boosting fat loss and increasing your endurance, energy and stamina. This PPAR modulator has been proven through valid research to have many health benefits but its performance benefits are its top advantages.

When it comes to fat loss, you’ll notice a major difference as well as an increase in vascularity as Cardarine promotes the burning of fat as a source of fuel. You’ll also see dramatically reduced recovery times after working out, and even a boost in your mood.

cardarine before and after
Cardarine 12-week cycle before and after photos
  • Incredible endurance enhancement
  • Dramatically reduced recovery time
  • Works from the first dose
  • Improves your mood
  • Enhances fat loss
  • Ideal for interval/cardio training
  • Stackable with other SARMs
  • Is NOT a stimulant and doesn’t increase heart-rate
  • Can be stacked with any other fat burners for maximum fat-burning potential

Read our blog to see more SARMs Before and After Photos.

How Does Cardarine Work?

Cardarine GW 501516 binds to the PPAR-delta nuclear receptors which are mostly in your muscles and stimulates some of the genes which govern how your body uses energy. By doing these two things, Cardarine can:

  • Help you burn more body fat – by preventing fatty acid chains from being formed, and therefore stopping your body from storing fat, so your system has to use stood fat for energy
  • Preserve existing muscle mass – when you are in an energy deficit and your body is forced to use fat for fuel, Cardarine can also protect muscle mass from catabolism
  • Faster recovery – Cardarine may increase the amount of oxygen which gets to your muscles, helping you recover from training sessions

Cardarine Review for Bodybuilding

1 Fat burning

Cardarine can help you burn more body fat by encouraging your body to use stored fat for fuel, by stimulating glucose, and by activating some of the genes involves in fat burning.

2 Bulking and cutting

Cardarine can be stacked with other SARMs to encourage fat loss, boost training performance, and help you maintain muscle mass when dieting – ideal for cutting and bulking cycles.

3 Brain health

Cardarine can improve blood flow to the brain, protecting brain vessels, boosting the growth of nerve cells, and reducing problematic inflammation.

4 Training endurance

Cardarine stimulates your body’s use of glucose for fuel, which means you can probably train longer and harder. More training = more muscle gain!

5 Muscle growth

Cardarine activates the PPAR-delta which boosts muscle fibres, gives you increased energy and means you can train for longer too.

6 Heart health

Cardarine may have a protective benefit for your blood vessels, reducing oxidative damage and plaque build-up, and increasing your levels of nitric oxide.

How To Dose Cardarine

Cardarine is kind of an all-rounder, you can use it for cutting or bulking cycles. It has a half life of 16 hours, so you will need to split your daily total dose into two doses. Start with 10mg/day (5mg twice per day), ideally with one dose 2-3 hours before you train. Run Cardarine for a maximum of 12 weeks, followed by a 6 week off-cycle break.

Can You Stack Cardarine?

A Cardarine Review wouldn’t be complete without some stack suggestions, so here they are! GW can be stacked with most other compounds. It mitigates fat-gain during bulking cycles, increases fat-loss during cutting cycles, and enhances endurance and performance all-round. Here are the most popular SARMs stacks:

Body-Recomposition Stack

  • Cardarine GW-501516
  • Ligandrol LGD-4033
  • Andarine S-4

Cutting Stack

  • Testolone RAD-140
  • Cardarine GW-501516
  • Stenabolic SR-9009
  • Andarine S-4

Strength Stack

  • Testolone RAD-140
  • Cardarine GW-501516
  • Andarine S-4

Bridging Stack

  • Andarine S-4
  • Ostarine MK-2866
  • Cardarine GW-501516
  • Stenabolic SR-9009

Endurance Stack

  • Cardarine GW-501516
  • Stenabolic SR-9009

Bulking Stack (with minimum fat-gain)

  • Cardarine GW-501516
  • Ostarine MK-2866
  • Ligandrol LGD-4033
  • Testolone RAD-140

Does Cardarine Have Any Side-Effects?

Like any compound, you should be sensible about using Cardarine. This includes looking out for side effects. Cardarine won’t suppress your natural hormone levels. It is always recommended to start off with lower doses and assess response and adaptation. If there is anything we haven’t covered in this Cardarine Review, see our Guide to Cardarine for more information.

Cardarine GW-501516: A Complete Guide to GW501516

Cardarine GW-501516: A Helpful Guide 2019

In this article, we’ll cover everything you need to know about the PPAR-delta activator Cardarine (GW-501516), how long it takes to work, the ideal cycle length, safety and vital information you need before you consider adding it to your supplement regime.

A lot of the compounds we write about at are SARMs (selective androgen receptor modulators). This article is about something a little different, although often classed into the same category. GW501516 can help burn fat, boost metabolism, increase training endurance and protect muscle tissue but it isn’t actually a SARM. It’s a non-hormonal PPAR-delta activator which doesn’t work on the androgen capacitors at all.

If you’re curious about Cardarine, here’s everything you need to know and if we haven’t covered something, simply e-mail us and we’ll be happy to answer your questions!

Is Cardarine (GW-501516) a SARM?

As we said, Cardarine isn’t actually a SARM (anyone who tells you it is doesn’t know what they’re talking about). A SARM activates androgen receptors in muscles and other tissue. Cardarine is a PPAR-delta activator but it can produce results similar to those of SARMs.

Background Information

The best way to understand what to expect from a compound is to look at why it was developed (and what was discovered by researchers). GW501516 was originally developed by a drug company in the 1990s as a way to prevent tumours (especially on the colon and prostate). But there were some surprising discoveries.

During their studies into increased endurance and fat burning, the researchers began to understand more about the PPAR-delta pathway. They realised that activation of this pathway had an astounding impact on muscle growth, endurance and energy whilst decreasing blood lipids and subcutaneous fat. And – you guessed it – the compound GW-501516 can bind to this PPAR-delta pathway.

It turned out Cardarine could help reduce body fat, boost metabolic rate, improve the strength of blood vessels. This has a positive impact on cardiovascular health, increases muscle growth rate and even reduces recovery time. We’ll go into these factors in greater depth later in this article.

One thing we need to make clear: Cardarine is not currently sold for human consumption. It is classed as a ‘research compound’, sold for research purposes only.

How Long Does Cardarine Take to Work?

It’s important to understand how the Cardarine works in the body. Like we’ve already said, it binds to PPAR-delta in muscle cells and it stimulates certain genes which facilitate the body’s use of energy. Once you know that, you can see how it can boost your metabolic rate, improve physical performance and even help burn more fat (whilst increasing and protecting muscle mass).

You’ll notice the effects almost instantly; timing one of your dosages about thirty minutes before a high-intensity training session is an ideal protocol. The difference in energy, endurance and stamina will be noticeable almost immediately.

Burn Fat & Recover Faster with GW-501516

How exactly does Cardarine burn body fat? It’s not as simple as just torching fat right off your body. It starts with preventing the formation of fatty acids chains which, in turn, stops your body actually storing fat. This means your body needs to tap into your subcutaneous fat stores for energy – just like when you diet. But there’s one big difference to when you burn body fat by dieting. GW-501516 has those sought-after anti-catabolic properties, which means you get leaner without losing valuable muscle tissue.

What about boosting recovery between training sessions? It seems Cardarine can help your muscle fibres (specifically the slow-twitch fibres) use oxygen more efficiently, and this can help improve rates of recovery between training. It can also mean better endurance during training sessions. Good news if you train for hypertrophy, with a lower-load and higher-rep style of training.

Cardarine & Bodybuilding

You can already guess that this is an attractive compound for bodybuilders with its potential for muscle gain, training recovery and fat burning. (Side note: it’s also getting a lot of interest with the nootropics crowd.)

Cardarine could be used by itself or with other compounds as a cycle; you can stack it with prohormones, SARMs or other fat-burners. You can also use it to bridge between cycles or throughout a PCT (post cycle therapy) phase. Either way, it should be cycled for best results. Plan your cycle length for 8-12 weeks before having a 4-8 week break.

GW501516 has a half-life of 12-24 hours so you can decide whether to split your dose or to take it once per day. A dosage of 10mg-20mg per day is recommended.

Stacking Cardarine with Other Compounds

Cardarine can be used as a standalone supplement but is often stacked with other compounds. Most commonly, it has great synergistic effects with MK-677, RAD-140, Ostarine, LGD-3303 and Andarine.

It can also be used to combat negative side-effects of some anabolics (such as Trenbolone) and address potential lipid health issues. Cardarine is beneficial during PCT because it can lessen your chances of a fat-regain or rebound after running a steroid or prohormone cycle.

7 Things You Need To Know About Cardarine

#1 Fat Burner

It boosts your body’s fat-burning capacity by stimulating glucose and activating the ABCA1 and CPT1 fat-burning genes. Interestingly, there was a human study done on Cardarine’s potential for receding fatty acids, VLDL proteins and triglycerides (human studies on Cardarine are pretty rare, so it’s worth a look at this one).

#2 Training Endurance

It can stimulate the body’s glucose uptake, encouraging your body to use glucose as its primary fuel source. This means you get more energised for training and can train harder for longer. Since Cardarine can activate PPAR-delta pathways, it can also improve strength endurance. This 2015 study (on mice) suggests Cardarine can increase the specific muscle fibres associated with peak training performance.

#3 Lean Gains

It is a popular choice for stacking with SARMs and other compounds to protect lean muscle tissue whilst dieting to get shredded. As we’ve said, it can help burn body fat without the problem of losing muscle mass or looking over-dieted and scrawny.

#4 Brain Health

It can have a positive effect on blood vessels (see #5) and this means protection for your brain blood vessels (plus more blood to the brain). You might also like to know PPAR activators are thought to boost nerve cell development of nerve cells.

#5 Cardiovascular Health

It can prevent oxidative damage to blood vessels, helping reduce build-up in the arteries and (most exciting for bodybuilders) increasing your nitric oxide (NO) levels. This could mean Cardarine may reduce inflammation and associated tissue damage – a key factor in recovery and muscle growth during hypertrophy.

#6 Liver & Kidney Health

MCP-1 activity is a key factor in kidney disease and Cardarine can reduce this activity. Additionally, Cardarine acts directly on your liver (a powerhouse for storing fats for fuel in the body), using PPAR-delta activation to use fatty acids for energy. Cardarine could even reduce the body’s production of IL-6 and thereby prohibit insulin resistance.

#7 Muscle fibres

Activating PPAR-delta also means Cardarine can encourage better muscle fibre development. This means increased training endurance and the potential for greater muscle growth.

Choosing & Using Cardarine GW-501516

The bottom line is that Cardarine GW501516 is not currently legal for human consumption so it is sold for research purposes. Not for training, cutting, bulking, or bodybuilding.

You also need to bear in mind that Cardarine is banned for any tested bodybuilding competitions (yes, even trace amounts found accidentally in another product). At the moment, almost all the (limited) research on Cardarine GW501516 is on animals.

Don’t risk wasting your money on cheap, fake dupes!

One of the best selling products Mutagenic Labz Amalgamation combines a blend of GW-501516 and SR-9009, a very effective fat-loss combo. If you’re not keen on Cardarine just yet, Check out Mutagenic Labz Assimilation – our safe, legal and insanely effective GDA (Glucose Disposal Agent) to help you get leaner and build more muscle faster.

Disclaimer: By publishing this post we are not recommending using GW501516. It’s our duty to inform and educate you on all compounds. All of the information we have given here can be corroborated by published scientific reviews and literature. We recommend Mutagenic Labz Assimilation.

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