Best Time to Take MK677: Morning vs Night Time

Best Time to Take MK677: Morning vs Night Time

The best time to take MK677 has become a point of interest for those seeking to maximize the benefits of this compound. Also known as Ibutamoren, MK677 has garnered significant attention for its potential to stimulate growth hormone levels and promote muscle growth and fat loss.

Yet, amid varying opinions and conflicting advice, the timing of MK677 administration remains a highly debated subject. In this article, we delve deep into the complexities surrounding the optimal dosing schedule of MK677, examining scientific insights and practical considerations to uncover its potential impact on effectiveness.

What is MK677, and how does it work?

MK677, also known as Ibutamoren, is a growth hormone secretagogue; a substance that stimulates the release of growth hormone from the pituitary gland and insulin-like growth factor 1 (IGF-1).

Despite being commonly referred to as a SARM, it doesn’t bind to androgen receptors like traditional SARMs. Instead, MK677 acts as a potent ghrelin receptor agonist, targeting the ghrelin receptor (GHSR) in the brain.

This case study shows effects of MK677 on body composition in healthy older adults:

To determine whether MK-677, an oral ghrelin mimetic, increases growth hormone secretion into the young-adult range without serious adverse effects, prevents the decline of fat-free mass, and decreases abdominal visceral fat in healthy older adults.

Conclusion: Over 12 months, the ghrelin mimetic MK-677 enhanced pulsatile growth hormone secretion, significantly increased fat-free mass, and was generally well tolerated.

Scientific Background:

Ghrelin is a hormone produced in the stomach and plays a crucial role in stimulating appetite and promoting growth hormone release from the pituitary gland. MK677 functions by mimicking the action of ghrelin, binding to and activating the ghrelin receptor in the hypothalamus. This activation leads to increased signaling in the growth hormone-releasing hormone (GHRH) neurons and subsequently the release of growth hormone from the pituitary gland.

Real-Life Applications:

  1. Increasing Growth Hormone Levels: MK677 is used to enhance growth hormone levels in individuals with growth hormone deficiency, and it can be beneficial for promoting growth in children with growth disorders.
  2. Muscle Mass and Strength: The elevation of growth hormone and IGF-1 levels by MK677 can help improve muscle mass, strength, and recovery in athletes and bodybuilders.
  3. Bone Density: MK677 may have potential benefits for increasing bone mineral density and bone health in certain individuals, especially the elderly and those with osteoporosis.
  4. Anti-Aging Effects: Some research suggests that increasing growth hormone levels with MK677 might have anti-aging effects, although more studies are needed to establish its long-term safety and efficacy in this context.
  5. Appetite Stimulation and Cachexia: MK677 has shown promise in stimulating appetite in individuals with certain medical conditions associated with decreased appetite, such as cancer-related cachexia and other wasting disorders.
  6. Improved Sleep Quality: Some users report improved sleep quality and better REM sleep when taking MK677, although individual responses can vary.

What Are the Common Side Effects of MK677?

Individual responses to MK677 can vary, and not everyone will experience all of these side effects. If someone is considering using MK677, it is vital to consult a healthcare professional to understand the potential risks and benefits based on their specific health profile. Additionally, proper dosage, timing, and cycling should be carefully considered to mitigate potential side effects.

  • Increased Appetite: MK677 is known to stimulate appetite, and some individuals may experience a significant increase in hunger while taking the compound.
  • Water Retention: Users may notice water retention or mild edema, which can lead to a bloated feeling or temporary weight gain.
  • Lethargy/Fatigue: Some individuals report feeling more tired or lethargic while taking MK677, which can be a result of hormonal changes or other factors.
  • Numbness or Tingling in Extremities: MK677 has been associated with a sensation of numbness or tingling in the hands and feet for some users.
  • Changes in Blood Sugar Levels: MK677 may cause fluctuations in blood sugar levels, particularly in individuals with existing glucose regulation issues.
Pumping Iron Ibutamoren (MK-677) 10mg x 60 Capsules
Pumping Iron Ibutamoren (MK-677) 10mg x 60 Capsules

Best Time to Take MK677: Morning vs Night Time

The best time to take MK677 depends on personal preferences, lifestyle, and the ability to manage its potential side effects. Some individuals may even choose to split their daily dosage, taking a portion in the morning and the rest before bedtime.

As you will see below, there are certain considerations to keep in mind and for each person, it will be a different experience. It is best advised to try the different protocols and decide for yourself which option works best for you:

Morning Administration:

  • May cause slight lethargy or decreased energy levels during the day
  • May cause slight appetite increase during the day
  • Some individuals prefer taking MK677 in the morning because their daily activities or busy work schedule allows easier management of appetite and energy levels
  • However, for other individuals, the increased appetite could be more noticeable during waking hours, and may be more challenging for those aiming to control their food intake or follow a specific diet plan

Nighttime Administration:

  • Some users find that taking MK677 before bedtime helps them better cope with the lethargy/fatigue side effect, as they can rest and sleep through this sensation
  • The growth hormone release stimulated by MK677 might be more in line with the body’s natural patterns, as growth hormone levels tend to peak during sleep
  • Some individuals prefer nighttime dosing so that they can sleep through some of the increased appetite side-effects
  • However, some individuals may find that dosing before bed will increase appetite enough to make it more difficult to fall asleep
  • The increased appetite associated with MK677 might be more noticeable in the evening, which could lead to overeating if not managed.

How Does Timing MK677 With Exercise or Training Sessions Impact Its Benefits?

The best time to take MK677 around your exercise or training sessions can have potential impacts on its benefits due to its ability to stimulate growth hormone release. Here are some considerations:

  1. Enhanced Recovery: Taking MK677 around the time of exercise or training sessions may promote enhanced recovery. Growth hormone plays a crucial role in tissue repair and muscle recovery, so increasing its levels during or after workouts might aid in the recovery process.
  2. Muscle Growth and Repair: MK677’s ability to increase growth hormone and IGF-1 levels can be particularly beneficial during periods of intense exercise, as it may support muscle growth and repair, leading to more significant gains in muscle mass over time.
  3. Increased Fat Loss: Some studies suggest that MK677 can aid in fat loss due to its effects on growth hormone and IGF-1, which may promote lipolysis (the breakdown of fat). Timing MK677 near workouts could potentially enhance fat-burning effects, especially in combination with appropriate exercise and diet.
  4. Strength and Performance: By optimizing growth hormone levels, MK677 may positively impact strength and performance, making it useful to take before strength training or high-intensity workouts to potentially enhance performance.
  5. Sleep and Recovery: As MK677 may cause lethargy or fatigue as a side effect, taking it at night after exercise might be more convenient for some individuals, as they can rest and sleep through this period, aiding overall recovery.
  6. Potential Appetite Stimulation: Timing MK677 around exercise might help manage the increased appetite side effect, as users can utilize the extra caloric intake to support their fitness goals, especially for individuals aiming to gain muscle mass.

Best Time to Take MK677: Will Timing Affect MK677 Effectiveness?

The best time to take MK677 is different for each individual and the best way is the way that works for you.

The effectiveness of MK677 will not be affected so much that it would be noticeable, so whichever way you choose, it will work and will be very effective.

However, if you want to understand more about timing and any influence to its effectiveness, here are some considerations:

  1. Growth Hormone Release: MK677 stimulates the release of growth hormone, and the body’s natural production of growth hormone tends to peak during certain periods, particularly during sleep. Taking MK677 at night might align with the body’s natural rhythm, potentially maximizing its impact on growth hormone levels.
  2. Sleep Disturbances: Some users report experiencing lethargy or fatigue as a side effect of MK677. Taking it at night might be more suitable for these individuals since they can rest and sleep through this period, potentially minimizing the impact of this side effect on daily activities.
  3. Appetite Stimulation: MK677 is known to increase appetite in many users. Taking it in the morning might be preferred by some individuals as they can manage the increased hunger throughout the day, while others might choose to take it later in the day to minimize the impact on their appetite during waking hours.
  4. Exercise and Training: Some users prefer to time their MK677 intake around their exercise or training sessions. By doing so, they might take advantage of its potential benefits on recovery, muscle growth, and performance. However, other users will find that the slight fatigue will negatively impact their motivation levels.

Should MK677 Be Taken With or Without Food?

MK677 (Ibutamoren) can be taken with or without food, as it does not require a specific type of administration in this regard. However, there are some considerations to keep in mind for each option:

  1. Taking MK677 with Food:
    • Advantages: Some users find that taking MK677 with a meal can help minimize potential stomach discomfort or nausea that might occur with its use.
    • Considerations: Taking MK677 with a meal could potentially slow down its absorption and onset of action, although this might not be a significant concern for most users.
  2. Taking MK677 on an Empty Stomach:
    • Advantages: Taking MK677 on an empty stomach might lead to quicker absorption and potentially faster effects, especially if you want to avoid any delay in its action.
    • Considerations: Some individuals may experience mild stomach discomfort or nausea when taking MK677 on an empty stomach, although this can vary between users.

What Is the Recommended Dosage of MK677?

The recommended dosage of MK677 (Ibutamoren) can vary depending on factors such as individual tolerance, experience with the compound, and specific health goals. It’s crucial to note that I am an AI language model, and I am not a medical professional. Therefore, I cannot provide personalized medical advice. However, I can provide some general dosage guidelines that are commonly referenced:

  • Typical Dosage Range: The typical dosage of MK677 for adults is usually in the range of 10 mg to 25 mg per day.
  • Start Low and Gradually Increase: It’s common for users to start with a lower dosage, such as 10 mg, and gradually increase the dose over time if needed, based on their response and tolerance to the compound.
  • Cycle Length: MK677 is often used in cycles, typically ranging from 8 to 12 weeks. After completing a cycle, it is recommended to take a break to allow the body to readjust before starting another cycle.

Are There Any Benefits of Splitting the MK677 Dosage Throughout the Day?

Some users choose to split the dosage of MK677, dosing once in the morning and once in the evening.

  1. Potential Mitigation of Side Effects: By dividing the daily dosage into multiple smaller doses, some individuals might experience a reduction in certain side effects associated with MK677, such as water retention and bloating.
  2. Improved Tolerance: For those who find higher single doses of MK677 uncomfortable or challenging to tolerate, splitting the dosage can make it easier on their digestive system and improve overall compliance.
  3. Optimal Hormonal Levels: Splitting the dosage can help maintain more consistent growth hormone and IGF-1 levels throughout the day, potentially maximizing the desired effects.
  4. Individualized Timing: Splitting the dosage allows users to tailor the timing of administration to their unique schedule and lifestyle, optimizing its effects based on their preferences and routines.
  5. Reduced Risk of Oversaturation: Some users believe that smaller, more frequent doses of MK677 are less likely to oversaturate the body’s receptors and lead to diminished effectiveness over time.

How Long Does MK677 Take To Start Showing Results When Taken at Different Times?

The time it takes for MK677 (Ibutamoren) to start showing results can vary from person to person and is influenced by various factors, including the individual’s physiology, dosage, and timing of administration. Here are some general guidelines on when users might start noticing effects based on different timing scenarios:

  1. Morning Administration: When taken in the morning, some users might experience increased appetite and potentially increased energy levels during the day relatively quickly, within a few days to a week. However, noticeable changes in muscle mass, strength, or body composition may take several weeks to a couple of months, as these effects typically occur gradually over time.
  2. Nighttime Administration: When taken at night, individuals might experience potential sleep disturbances, such as lethargy or fatigue, during the initial days of usage. Other effects, such as enhanced recovery and potential improvements in muscle mass and fat loss, may become apparent after several weeks to a few months of consistent use.

It’s important to note that MK677 is not a quick-fix supplement, and individual responses can vary significantly. Some users might see noticeable changes earlier, while others might require more time to experience the full effects.

Moreover, the benefits of MK677 are often seen when it is used in conjunction with a well-structured diet and appropriate exercise regimen. Consistency with dosing and lifestyle factors will play a role in determining how quickly results manifest.

As with any supplement, it’s essential to manage expectations and not solely rely on MK677 to achieve specific fitness goals.

Is There an Ideal Time To Take MK677 for Maximising Muscle Growth?

There is no universally agreed-upon “best time to take MK677” for maximising muscle growth, as individual responses can vary based on several factors.

However, there is one consideration to keep in mind when using MK677 to support muscle growth:


Whatever time you choose to take MK677, it’s essential to be consistent with the timing every day to maintain steady growth hormone levels and optimize its effects on muscle growth.

Consistency is crucial with MK677 for optimal results primarily because of its relatively long half-life, which is approximately 24 hours.

The half-life refers to the time it takes for half of the drug to be eliminated from the body. Since MK677 has a long half-life, maintaining regularity in dosing ensures a steady and sustained presence of the compound in the bloodstream.

This consistency is essential for maintaining stable growth hormone levels throughout the day, as MK677 stimulates the release of growth hormone and insulin-like growth factor 1 (IGF-1).

By adhering to a consistent dosing schedule, users can potentially maximize the impact of MK677 on muscle growth, recovery, and other desired outcomes, as fluctuations in dosing could result in uneven hormonal effects.

Moreover, consistent dosing allows the body to adjust and optimize its response to MK677 over time, contributing to more predictable and potentially more significant benefits.

Ultimately, the best time to take MK677 is at a consistent time every 24 hours.

Does Taking MK677 at Specific Times Influence Its Impact on Fat Loss?

Taking MK677 (Ibutamoren) at specific times may influence its impact on fat loss, primarily due to its effects on growth hormone and insulin-like growth factor 1 (IGF-1). However, it’s important to note that the effects of MK677 on fat loss can vary from person to person, and individual responses may differ. Here are some considerations regarding the timing of MK677 administration and its potential influence on fat loss:

  1. Nighttime Administration: Some users prefer taking MK677 at night, as it might help manage the side effects, such as increased appetite or lethargy, during waking hours. Additionally, growth hormone levels naturally peak during sleep, and nighttime administration might align with the body’s natural rhythms, potentially enhancing the fat-burning effects during this period.
  2. Before or After Exercise: Taking MK677 before exercise might provide benefits for fat loss, as elevated growth hormone levels can enhance lipolysis (breakdown of fat) during physical activity. On the other hand, taking MK677 after exercise might support the recovery process, which is essential for overall fat loss and body composition improvements.
  3. Consistency and Individual Response: While timing may play a role, consistency in MK677 administration and individual response to the compound are crucial factors. Some individuals might experience more pronounced fat loss effects with MK677, while others may not see significant changes in body composition.
  4. Diet and Exercise Synergy: MK677 is not a magic pill for fat loss, and its effects are most likely to be enhanced when combined with a proper diet and exercise program aimed at fat loss and body composition improvements.
  5. Appetite Stimulation: MK677 is known to increase appetite in many users. The timing of MK677 administration may affect how this increased appetite is managed and incorporated into the overall diet strategy for fat loss.

It is essential to keep in mind that while MK677 might have some potential effects on fat loss due to its influence on growth hormone and IGF-1, it is not a substitute for lifestyle changes or a well-balanced approach to weight management.