Best SARMs Stack for Cutting

Best SARMs Stack for Cutting (Updated 2022)

SARMs are getting increasingly more popular amongst bodybuilders, competitors and athletes, so one of the most common questions we get is to recommend the best SARMs stack for cutting. It’s not surprising when you consider that these compounds can help build muscle, give a denser, harder look to muscle and help burn body fat beyond our natural potential.

That’s the holy grail – adding mass and not losing it again when you diet! Not to mention, to speed up the process of losing body fat and revealing those chiselled abs!

Which are the best SARMs for fat loss? Here’s our take on it…

What Are SARMs & How Do They Work For Dieting?

SARMs are “selective androgen receptor modulators”, compounds which selectively bind to androgen receptors in the body’s tissues to help manipulate our natural hormone levels. Androgens are hormones which signal the body to make changes – like the way testosterone signals the body to grow.

By binding to some of the receptors which receive these hormonal messages, SARMs can specifically boost some of those signals. The key here is in the “selective” part of the name. SARMs don’t bind to every receptor (unlike anabolic hormones, which do). They only bind to receptors in bone tissue and muscle tissue. This selective nature means you get more specific in what you want the SARM to do, and you can avoid a lot of the side effects associated with steroids.

Most SARMs were initially developed as a possible way to create certain medical conditions, specifically those related to loss of bone density, muscle mass, and strength. They caught the eye of researchers because they were able to bind only to the affected tissues, and not to anything else like internal organs.

SARMs can be taken as orals which makes them easier and more user-friendly than anabolics.

But what about using SARMs for fat loss? In this article, we will look at how to use SARMs for cutting (fat loss dieting) whether you want to do that for your health, your appearance, or as a bodybuilder.

The Best SARMs for Cutting

In order to put together the best SARMs stack for cutting, we’ll take a look at the different SARMs that are best for fat loss, and the reason why they make a good choice for your dieting phase.

Each of the different compounds below has superb fat-shedding qualities and these are often interchanged depending on the preferences of the individual user. In short, the best SARMs stack for cutting is the one that works for you! See which compounds fit your preferences and do your research – that is always the best way.

Andarine S4

Andarine, or S4, is a strong and potent SARM which is thought to increase fat oxidation and reduce lipoprotein lipase which is linked to fat accumulation in the body. Initially developed to combat conditions such as osteoporosis and muscle wastage, S-4 is one of the most researched SARMs which is always a positive aspect.

Andarine also helps increase muscle mass and strength. Even low doses of Andarine can help you maintain all your gains when you go into a calorie deficit to get lean. All in all, a good choice for cutting or body recomposition.

Best dose: start at 25mg/day split into 2-3 doses (4-6 hours apart), never go higher than 50mg/day and keep cycles to an 8-12 week maximum.

Ostarine

Ostarine MK 2866 really helps boost muscle gain because it increases the body’s levels of nitrogen and protein. This makes it a good choice for protecting muscle mass when you diet, avoiding that stringy, over-dieted look.

LGD-3303 (Not LGD-4033!)

A quick update here: LGD-3303 has now been patented by pharmaceutical company Ligand Pharmaceuticals Incorporated and is no longer available on the market.

LGD-3303 is a potent and highly selective androgen receptor full agonist in skeletal muscle, a classic target tissue for androgen action. By comparison, in the prostate and sebaceous glands, the compound is a weak partial agonist. The sparing of these non-target tissues by effective, pharmacologic doses of LGD-3303 provides a novel and potentially safer treatment for osteoporosis.

Source: Ligand Pharmaceuticals Incorporated

Here’s where our recommendation on the best SARMs stack for cutting is different from any other you may have seen online. Most will recommend Ligandrol but we beg to differ. LGD-3303 is the leaner, dryer, fuller and more vascular successor of Ligandrol (LGD 4033). For that reason, it undoubtedly takes the throne.

Cardarine

Cardarine GW 501516 isn’t actually a SARM but a PPAR gamma receptor agonist that binds to PPARδ receptors instead of androgen receptors like a SARM normally would.

Cardarine supports healthy cholesterol levels and increases your basal metabolic rate, which helps your body to burn more energy (aka fat) even when at rest. You might also feel an energy boost, which definitely helps when you are dieting in a calorie deficit! Cardarine is a compound we stack with pretty much anything; this one’s a winner all-round… even when bulking to mitigate fat gain.

Stenabolic

Stenabolic SR 9009 is another on this list which isn’t actually a SARM (it’s a REV-ERB agonist) but it deserves a place on this list. As a REV-ERBα agonist, it can help manipulate certain functions relating to the metabolism, so you feel more energised, burn more stored fat, and get a boost to your metabolic rate even at rest. Stenabolic is also a compound we love to stack with pretty much anything.

MK-677

MK-677 is a growth hormone secretagogue and stacks well with virtually anything. It is a very versatile compound that can be used for both bulking or cutting, depending on the accompanying diet and training plan (increased calories will support bulking and reduced calorie intake supports fat loss).

Glucose Disposal Agents

Although Glucose Disposal Agents aren’t SARMs, they deserve a mention. Nutrient partitioning often gets forgotten about but is so effective when it comes to body composition. A glucose disposal agent decreases the amount of insulin secreted by the body when eating a high-carbohydrate meal and shuttles glucose into muscle cells instead of storing them in fat cells. This results in reduced fat gain and a potential increase in lean muscle gain.

The Best SARMs Stack for Cutting

As we’ve already pointed out, you can stack different SARMs to assist you during a cut and there are different ways to mix and match the compounds that work best for the individual.

One of the best SARMs stack for cutting we’ve researched is for the more advanced and experienced:

  • Andarine S-4 – 50mg per day, 25mg in the a.m. and 25mg 4-6 hours later
  • Ostarine MK-2866 – 20mg per day, dosed once a day in the a.m.
  • GW/SR (SR-9009/Cardarine Blend) – 1 capsule in the a.m, 1 capsule in the p.m.
  • MK-677 – 20mg per day, dosed once per day (can be reduced to 10mg if appetite increase is unmanageable).

5 Keys To Getting Shredded

Remember that there are several aspects to getting that lean, shredded look. Sure, you need to reduce your body fat. But you also want to increase muscle mass, and – crucially – retain as much muscle as possible even as you diet to lose fat. It’s a difficult task, but SARMs can make it much easier.

1 A calorie deficit

You need to be in a calorie deficit to lose body fat, it doesn’t matter what kind of diet you follow – a calorie deficit is crucial. This means making sure your total “calories out” are higher than your “calories in”

2 Sufficient protein intake

Eating enough protein will help you build muscle, maintain muscle, and it will help keep you feeling fuller (protein has the highest Thermic Effect Of Food of any macronutrient) which will help diet compliance

3 Training frequency

We now know that training frequency is the most important factor in muscle gain and muscle retention, ideally train each major muscle group every 72 hours

4 Load and volume

Within that training, you need to put enough load (weight) and volume (weight x sets x reps) through the muscles

5 Appetite and energy management

Get control of your appetite, eating habits, and your energy output to increase your success with getting super-lean and shredded!

What’s the Best PCT for SARMs?

Although PCT is a very subjective matter, it’s often recommended to run a PCT such as Pro PCT (6-OXO).

Pumping Iron Pro PCT (6-OXO) is an advanced SARMs and prohormone PCT that contains 6-OXO, a potent aromatase inhibitor which should only be used by experienced users of SARMs and prohormones. This supplement is intended for male athletes only and shouldn’t be used by women. PRO PCT can be used to prevent estrogen related side effects on-cycle as well as a powerful recovery agent for post cycle therapy (PCT)

  • Strongest aromatase inhibitor on the market
  • Increases lean muscle mass
  • Reduces conversion of testosterone to estradiol
  • Supports muscle retention
  • Increases testosterone:estrogen ratio
  • Suitable for vegans (HMPC Veg Cap)

 

The Best Prohormones for Cutting

Best Prohormones for Cutting (Updated 2022)

The best prohormones for cutting and getting shredded are those that don’t cause water retention and provide the chiselled, well-defined physique throughout the cycle.

Getting lean and shredded is one of the most popular goals on the gym floor. Every guy wants to get super-lean at least once in his life. And when you decide to do it you’ll want to go all out. After all, there’s no point grinding through a diet and doing extra cardio if you’re only going to get mediocre results at the end of it.

If you’re planning your next cut, you might be wondering whether SARMs or prohormones could help you get that bit leaner than before…

The answer is yes, there are compounds out there that can help you burn more fat, get leaner and – crucially – hang on to muscle whilst you melt away fat.

What are the best prohormones for cutting? Let’s find out.

What Are Prohormones?

Pro hormones are different from SARMs and they are definitely not anabolic steroids either. Prohormones are really “pro-steroids”) because they act as precursors to anabolic growth hormones in your body, encouraging your body to churn out more of those muscle-building, fat burning, strength gaining hormones.

Are Prohormones Legal?

You need to do your research about the legality of prohormones (which is why you’re here!) In the USA, a lot of prohormones were banned under the 2014 Designer Anabolic Steroid Control Act of 2014 in the USA. That said, a few remain outside of this ban. These currently include:

  • 1-Androsterone (1-DHEA or 1-androstene-3b-ol-17-one)
  • 4-Androsterone (4-DHEA or 4-androstene-3b-ol-17-one)
  • 1,4-OHP
  • Epiandrosterone (Epi-Andro)
  • 6-Keto-progesterone

And do remember that all prohormones are banned by WADA, so if you are planning on doing any tested competitions – included natural or drug-free bodybuilding contest – you won’t be able to use prohormones at all.

How Do Prohormones Help You Get Leaner?

If you are thinking about using prohormones on your next cutting diet, you will want to know exactly how they would potentially help. The best prohormones for cutting and getting shredded are those that don’t cause water retention and provide the chiselled, well-defined physique throughout the entirety of the cycle.

As you know, there are a few factors that lead to some dropping body fat, retaining muscle and rocking that lean, full look.

1 Losing body fat.

The key to this is a calorie deficit, but anything that helps boost the metabolism and hang on to lean muscle will help. Prohormones can do both those things.

2 Energy output

The more energy you can burn (as long as you don’t overeat to compensate!) the more fat you’ll lose. Prohormones can give you an energy boost and training endurance.

3 Training intensity

You need to lift heavy and often to burn fat and keep muscle on in a diet. Prohormones give you the energy and drive that you need to train through a deficit.

4 Muscle retention

The more muscle tissue you can retain on a diet, the better you’ll look (and the healthier your metabolic rate will be). Prohormones can help you keep hold of more muscle.

Prohormones act as a precursor to the hormones testosterone and dihydrotestosterone, encouraging your endocrine (hormonal) system – including your pituitary and thyroid glands – to use this excess of anabolic hormones to build more muscle.

The Best Prohormones For Cutting

Here are the three most popular and effective prohormones for rapid fat loss on a cutting diet.

  1. Pumping Iron Pro DMZ is a blend of methylstenbolone and dymethazine for extreme mass and strength gains. Expect dry, hard muscle gains, fast fat loss, amazing pumps and a full lean look to your physique.For advanced users only.
  2. Pumping Iron M-Tren gives amazingly dry, lean gains in muscle mass so you can expect at increasing strength and visible physique changes, no bloat, no water retention and full muscles. Great for a body recoup or cutting cycle.
  3. Pumping Iron S-DROL is the original. The legend – extreme gains in size, power, strength, harness, vascularity and fat loss.

When you’re supplementing with prohormones, it’s important that you use the right product depending on your goals. The best prohormones for cutting are considered ‘dry’ compounds.

Prohormones fall into two main categories; wet and dry. A ‘wet’ compound will cause you to retain water during the cycle and generally be bulkier, which aids muscle protein synthesis (these prohormones are usually more potent than the dry compounds). This is great if you’re bulking but not so much if you want visible abs.

The other options are ‘dry’ compounds. These compounds will cause you to shed water and will often increase muscle hardness and fullness, as well as density and vascularity.

Stacking Prohormones

You can stack prohormones or just get the blends such as the Mutagenic Labz Mutation-X mentioned above which has done the lab work for you. Unless you are an advanced user, we don’t think it’s worth the risk of working out your own stack when you can buy a combined product that has already been created by experts.

If you’re ready to stack, we would recommend stacking Androtest and one other product.

When stacking prohormones, bear in mind that you do not need to run the products at full doses as you would if taken alone.

Prohormone Side Effects

You wouldn’t take any medication or drug without checking potential side effects, would you? So the same goes for prohormones.

Some people report increased blood pressure, acne, hair loss, liver stress, or reduced HDL cholesterol from prohormone use.

We think the best way to try and avoid any of this is by purchasing quality, trusted products (rather than trying to stack your own), always sticking to the dosage recommendations, never running a super-long cycle and always doing a PCT and natural testosterone booster afterwards to look after your health.

How To Take Prohormones For Dieting

If you buy prohormones from a trusted source, you’ll also be getting the best advice about doses and cycle length. Stick to this advice, don’t be a hero and just rely on the product to do its job.

Remember, even prohormones can’t help you lose fat if you aren’t also dieting. They’re not a magic pill (although they might feel like it!) so be sure you have your diet in check, your training is intense and regular and you stay active with a good step count or extra cardio if you have a sedentary lifestyle.

What’s The Best Cycle Support for Prohormones?

As with any pro-hormone, long term use of prohormones could have adverse effects on your liver, so you should use cycle support such as TUDCA.

The Pumping Iron TUDCA is a state of the art liver detox product that works perfectly as a detox product alone or alongside a prohormone cycle. A crucial aspect to successfully running your prohormone cycle is preserving your best health, so you can feel well in your body and revitalised after your post cycle therapy to enjoy your new-found strength and results in the long term.

What’s the Best PCT for Prohormones?

After taking pro hormones you should run a PCT such as Pro PCT (6-OXO).

Pumping Iron Pro PCT (6-OXO) is an advanced SARMs and prohormone PCT that contains 6-OXO, a potent aromatase inhibitor which should only be used by experienced users of SARMs and prohormones. This supplement is intended for male athletes only and shouldn’t be used by women. PRO PCT can be used to prevent estrogen related side effects on-cycle as well as a powerful recovery agent for post cycle therapy (PCT)

  • Strongest aromatase inhibitor on the market
  • Increases lean muscle mass
  • Reduces conversion of testosterone to estradiol
  • Supports muscle retention
  • Increases testosterone:estrogen ratio
  • Suitable for vegans (HMPC Veg Cap)
Stenabolic SR9009 - The Secret Fat Loss Wonder Drug

Stenabolic SR9009 – The Secret Fat Loss Wonder Drug (Updated 2021)

We write about SARMs at Pumping Iron Store but this is something a little different. Although you will often hear Stenabolic SR9009 talked about in the same conversation as SARMs, it is not, in fact, a SARM. This article will tell you about Stenabolic, why it was developed, what it is, the benefits and side effects and what to expect.

Although Stenabolic SR9009 was developed to study the circadian rhythm, studies have shown this drug to improve the overall health and quality of life of anyone who uses it. Dubbed as ‘exercise in a bottle’, research on Stenabolic shows that it can help to lose weight, decrease cholesterol, inflammation and even anxiety.

What Is Stenabolic SR9009?

As we have briefly mentioned, Stenabolic is not a SARM. It is a compound that was developed by researchers in a bid to treat or manage medical conditions. Stenabolic is a REV-ERB (specifically a REV-ERBα antagonist) which means it impacts the metabolism, including the circadian rhythm. It’s pretty complicated to explain, but here’s our best layman’s version:

Your body’s circadian rhythm is a pattern your system cycles through every 24 hours. Experts think it is linked to sunrise and sunset. It governs things like sleep, waking, energy levels, and hunger. Part of the cycle that keeps your circadian rhythm going involves “switching” genes on and off throughout the 24-hour cycle.

Stenabolic was initially developed for its effects on the circadian rhythm and was found to improve mood, control anxiety, reduce inflammation, and even have a positive impact on weight gain. Sounds good for bodybuilding, right?

Stenabolic was also found to increase the activity of REV-ERB nuclear hormone receptors, and this boosts the bioavailability of nutrients in your body. For us as bodybuilders, this means better nutrient uptake and more of the nutrients we eat gets to our muscle tissue.

One thing you must consider about SR9009 is that there is no human research on it. There’s plenty of research from animal studies (especially mice studies) but none on human subjects. There is plenty of anecdotal evidence and feedback from guys who use it to augment their training. So be sure to go into this with your eyes open and full awareness of the lack of human research.

How Does Stenabolic SR9009 Work?

The processes behind SR9009 are pretty complicated and well beyond a short article here. If you’re the deep-dive research kind of reader, take a look at this paper published in Nature Reviews Drug Discovery in 2014 or this 2016 paper published in the International Journal of Molecular Sciences.

SR9009 has a significant impact on REV-ERBA, which impacts circadian control and has knock-on effects on the immune system, sleeping patterns, energy production, and general activity.

Activation of Rev-ErbA-α by SR9009 increases exercise capacity by increasing mitochondria counts in skeletal muscle.

REV-ERB is particularly influential in the tissues of the muscles, body fat, and liver. This suggests it could help boost fat burning, “switching off” the genes which store fat and increasing the number of mitochondria in the muscles.

OK, that’s a lot of scientific talk (and a couple of papers for you to look at). But what about the real-life stuff – how does SR 9009 benefit bodybuilders and people who want to get big, ripped, and lean?

Benefits of Stenabolic SR9009

  • Increases oxygen consumption
  • Prevents the creation of new fat cells in the liver
  • Increases the number of mitochondria in the muscle cells
  • Increases glucose and lipid metabolism
  • Decreases triglyceride levels in the blood
  • Reduces cholesterol breakdown in the liver
  • Promotes fat loss through glucose consumption
  • Regulates blood sugar levels
  • SR9009 has even been used to treat type-2 Diabetes
  • Delays the ageing process
  • Reduces inflammation
  • Decreases anxiety

1 Weight loss & fat loss

SR9009 has been shown to increase weight loss even without altering dietary intake. It has also been shown to reduce amounts of free fatty acids, triglycerides, and cholesterol. It could be great as a fat burner when you’re dieting or trying to get rid of that last bit of body fat.

2 Mood & energy

SR9009 is thought to be able to affect sleep patterns, which is beneficial to recovery and general health. It has been shown to increase energy levels and could even be used to increase wakefulness. Some studies also suggest SR 9009 could reduce anxiety.

3 Endurance

SR9009 has been shown to increase the total amount of mitochondria, which has a direct impact on endurance levels for physical activity. More endurance = more training = more gains.

4 Reduced inflammation

Inflammation can pose a big problem for bodybuilders who train hard, and Stenabolic SR9009 may be able to tackle this issue (by reducing TNF alpha in the body – these cells are a key player in systemic inflammation).

Does Stenabolic Have Side Effects?

We don’t know of any side effects with Stenabolic SR 9009 but there haven’t been any human studies so it’s difficult to say this with total confidence.

Stenabolic has shown no liver toxicity.

However, we do know that SR9009 doesn’t impact the body’s natural hormone levels so you won’t need to run a PCT if you use Stenabolic.

Best Dosage & Cycle Length for Stenabolic

Stenabolic has a half-life of 4 hours so you’ll need to split your total daily dose into 2-3 doses per day. So, if you’re taking 20mg/day, take 5mg every 4 hours (say, at 8 am, 12 pm, 4 pm, 8 pm).

Start at 10mg-20mg/day (maximum) and increase only to 30mg if you need to.

Most will run Stenabolic SR9009 cycles of 8-12 weeks, followed by the same time off.

Does SR-9009 Require a PCT?

Stenabolic (SR-9009) is not suppressive and does not generally require a PCT.

Best Testolone RAD-140 Dosage

RAD-140 Dosage and Complete Cycle Guide for Maximum Gains

Arguably one of the most talked-about compounds on the bodybuilding scene today, we’re going to look at the optimum RAD-140 dosage and cycle protocol that will give you the gains that you’re looking for.

RAD 140 – also known as Testolone – is a popular SARM with benefits including muscle gain and fat loss. But, as with any compound, it’s important that anyone considering to research Testolone knows the best RAD-140 dosage and cycle protocols to take. So here is everything we currently know about what dose to use, cycle length and stacking methods for best results.

What is RAD-140?

Testolone was developed as an investigational drug which might be able to treat muscle wasting diseases and help patients build muscle. It is a SARM (selective androgen receptor modulator), which works by selectively binding to some androgen receptors in the body – specifically those in muscle tissue and bone tissue. These receptors “talk to” the steroid hormones called androgens, including testosterone.

RAD 140 is thought to help increase muscle mass, boost fat burning and fat loss, and may even have neuroprotective benefits. It is also popular with men who are experiencing low testosterone levels and want to boost their physical performance and physique alongside getting their test levels up.

However, there have been no human studies on RAD 140 so far, and the long term risks and benefits are unknown. As with any SARM, do your research.

Like all SARMs, RAD 140 is on the WADA banned list so you should not use it if you are going to compete in tested events or take part in professional sports.

5 Benefits of Testolone

SARMs are popular with bodybuilders and people wanting to get bigger, stronger, and leaner. RAD 140 is no different in that respect. Here are the top benefits of Testolone for people who train in the gym.

1 Muscle growth

RAD 140 boosts the body’s development of proteins and muscle cells and can help stimulate muscle growth. Because SARMs are selective in the receptors they bind to, RAD 140 shouldn’t give unwanted side effects.

2 Repair and recovery

RAD 140 has been found to trigger the MAPK pathway which plays a part in protecting and repairing cells, and some users report better sleep. In one study scientists were able to use RAD-140 to activates receptors in damaged sections of the brain. The resulting reaction was a signal known as the MAPK pathway which is known to protect brain cells.

3 Bulking

Some SARMs are stronger and better for muscle gain, others are good for cutting. RAD 140 seems to be a better choice for a bulk.

4 Brain health

RAD 140 interacts with androgen receptors, and androgens are important for protecting brain health. RAD 140 may be able to help improve memory and cognitive health.

5 Fat loss

RAD 140 has been shown to improve cholesterol levels and boost muscle mass which can also help you burn fat and get leaner for better body composition.

With all these potential benefits, it’s no surprise bodybuilders are attracted to Testolone for training, fat loss, muscle gain, and recovery.

Best RAD-140 Dosage and Cycles

The lack of human studies means it’s difficult to give specific advice on how to dose RAD 140, but we can tell you what other people do. Anecdotal evidence is currently the best source of information regarding the research of SARMs. Below are some examples of popular RAD-140 dosage and cycle research methods.

Male esearchers begin at a dose of 10mg/day and increase to no more than 30mg/day.

Although RAD-140 is not recommended for women, those who do decide to research this drug will start with 5mg/day and increase to no more than 10mg/day.

A cycle length will generally last between 8-12 weeks following by a 4-week PCT and “off-cycle” break period.

RAD-140 is suppressive. It is critical that you are familiar and prepared with your PCT protocol before you start your cycle to avoid unwanted side-effects.

Some people stack Testolone with other SARMs, popular choices seem to be Ligandrol (for bulking), Ibutamoren, Ostarine, or Cardarine (for cutting).

Best RAD-140 Dosage for Bulking

The best RAD-140 dosage for gaining mass is 20mg-30mg/day for 12 weeks, with an off-cycle of 12 weeks. This lengthen cycle means you get maximum benefits of the strength gains, so you can train harder and lift more for the duration of a successful bulk. You’ll avoid most of the training fatigue typically experienced during a serious training block, and consequently, you’ll be able to keep training harder and increase your lifts throughout your bulking cycle.

RAD-140 Bulking Cycle

Testolone RAD-140 – 10mg per day, dosed once a day in the a.m.
Ligandrol LGD-4033 – 10mg per day dosed once a day in the a.m.
Ostarine MK-2866 – 25mg per day, dosed once a day in the a.m.

Best RAD-140 Dosage for Cutting

Testolone can also be used on a cut. Remember, it was originally developed to help prevent muscle wastage – and this is exactly what you want to do when you are in an extended calorie deficit. If you can hang on to more muscle when you are dieting, not only will you look better but your metabolic rate will stay higher.

The best RAD-140 dosage for cutting is slightly lower than that of a bulking phase if you are in a caloric deficit and primarily aiming for its anti-catabolic properties.

RAD-140 Cycle for Cutting

Testolone RAD-140 – 10mg per day, dosed once a day in the a.m.
Cardarine GW-501516 – 20mg per day, dosed once a day in the a.m.
Stenabolic SR-9009 – 30mg per day, 5mg split doses 2-3 hours apart

Best RAD-140 Dosage for Recomposition

Body-recomposition allows a person to build lean muscle mass whilst dropping body fat simultaneously. We said it here, yes it’s possible to lose body fat and gain muscle at the same time. With that in mind, the RAD-140 dosage is higher than on a ‘cut’ and adding Andarine into the mix to maximise lean gains.

RAD-140 Cycle for Body-Recomposition

Testolone RAD-140 – 20mg per day, dosed once a day in the a.m.
Cardarine GW-501516 – 20mg per day, dosed once a day in the a.m.
Stenabolic SR-9009 – 30mg per day, 5mg split doses 2-3 hours apart
Andarine S-4 – 50mg per day, 25mg in the a.m. and 25mg 4-6 hours later

Best RAD-140 Dosage for Strength

This stack makes use of the powerful synergistic effects of RAD-140 and S-4 when stacked together. Throwing Cardarine into the mix further maximises performance, which ultimately carries over to strength gains.

RAD-140 Cycle for Strength & Power

Testolone RAD-140 – 20mg per day, dosed once a day in the a.m.
Cardarine GW-501516 – 20mg per day, dosed once a day in the a.m.
Andarine S-4 – 50mg per day, 25mg in the a.m. and 25mg 4-6 hours later

Best RAD-140 Dosage for Lean Gains

This stack is the same as the re-composition stack but your own diet manipulation is what comes into play. Increasing your calorie and/or protein intake will optimise results for lean mass gains, increasing muscle protein synthesis whilst mitigating fat gain.

RAD-140 Cycle for Maximum Lean Mass Gains

Testolone RAD-140 – 20mg per day, dosed once a day in the a.m.
Cardarine GW-501516 – 20mg per day, dosed once a day in the a.m.
Stenabolic SR-9009 – 30mg per day, 5mg split doses 2-3 hours apart
Andarine S-4 – 50mg per day, 25mg in the a.m. and 25mg 4-6 hours later

Does Testolone Need A PCT?

All SARMs have the potential to suppress the body’s natural hormone levels and impact testosterone production, to varying degrees.

RAD-140 is one of the more potent SARMs and it is suppressive. It is critical that you are familiar and prepared with your PCT protocol before you start your cycle to avoid unwanted side-effects.

cardarine review photos blog

Cardarine Review: Your Guide To GW-501516

Read our Cardarine review to understand what it is and why it seems to be shaking things up in the bodybuilding industry! What exactly is Cardarine and what are the benefits for muscle gain and fat loss?

Cardarine (also known as GW 501516) is a very interesting compound that you might have seen cropping up more and more in the bodybuilding and fitness community recently. It is often referred to as a SARM, mainly because it’s often found in the same category as other SARMs and often stacked alongside them. GW actually a PPAR-delta activator. In this article, we discuss what this means, how GW501516 works and why many bodybuilders are turning to Cardarine to help them gain muscle, lose fat, improve their physique and train harder in the gym.

What is Cardarine GW 501516?

Although some people call Cardarine a SARM, it is not actually a selective androgen receptor modulator. Cardarine is actually a PPAR-delta activator but it works in similar ways to a SARM and that’s why bodybuilders and gym trainees are attracted to it for muscle gain, strength gain and fat loss.

Cardarine was originally developed as a potential medical asset for prevention of tumours but it soon showed other benefits: it could help reduce body fat, control body weight, raise the metabolic rate, increase rates of muscle growth, and boost endurance. No wonder bodybuilders are keen to take a closer look!

Like all drugs of its type, Cardarine is banned by WADA and can not be used in professional sport or in any tested competitions – that includes drug tested bodybuilding contests.

Cardarine Review Alongside Trenbolone

Cardarine pairs well with Trenbolone because it can counteract a lot of the negative side effects such as night sweats, reduced endurance, loss of libido, shortness of breath, increased blood pressure and a poor balance between cholesterol levels (high LDL and low HDL).

Tren severely reduces your cardiovascular potential so using Cardarine alongside a Tren cycle makes a very noticeable improvement. Cardarine improves endurance levels and helps athletes to push further, recover faster and greatly improves their cardiovascular health.

Studies have shown that GW-501516 has a positive impact on the balance between HDL and LDL cholesterol which can offset the negative side effects of Trenbolone.

In one study, Cardarine increased HDL cholesterol and decreased triglycerides, insulin, and LDL cholesterol, which may altogether decrease the risk of heart disease.

A number of studies have also shown that Cardarine helps to lower high blood pressure.

Cardarine Review – Before & After Photos

Cardarine is one of the best compounds when it comes to boosting fat loss and increasing your endurance, energy and stamina. This PPAR modulator has been proven through valid research to have many health benefits but its performance benefits are its top advantages.

When it comes to fat loss, you’ll notice a major difference as well as an increase in vascularity as Cardarine promotes the burning of fat as a source of fuel. You’ll also see dramatically reduced recovery times after working out, and even a boost in your mood.

cardarine before and after
Cardarine 12-week cycle before and after photos
  • Incredible endurance enhancement
  • Dramatically reduced recovery time
  • Works from the first dose
  • Improves your mood
  • Enhances fat loss
  • Ideal for interval/cardio training
  • Stackable with other SARMs
  • Is NOT a stimulant and doesn’t increase heart-rate
  • Can be stacked with any other fat burners for maximum fat-burning potential

Read our blog to see more SARMs Before and After Photos.

How Does Cardarine Work?

Cardarine GW 501516 binds to the PPAR-delta nuclear receptors which are mostly in your muscles and stimulates some of the genes which govern how your body uses energy. By doing these two things, Cardarine can:

  • Help you burn more body fat – by preventing fatty acid chains from being formed, and therefore stopping your body from storing fat, so your system has to use stood fat for energy
  • Preserve existing muscle mass – when you are in an energy deficit and your body is forced to use fat for fuel, Cardarine can also protect muscle mass from catabolism
  • Faster recovery – Cardarine may increase the amount of oxygen which gets to your muscles, helping you recover from training sessions

Cardarine Review for Bodybuilding

1 Fat burning

Cardarine can help you burn more body fat by encouraging your body to use stored fat for fuel, by stimulating glucose, and by activating some of the genes involves in fat burning.

2 Bulking and cutting

Cardarine can be stacked with other SARMs to encourage fat loss, boost training performance, and help you maintain muscle mass when dieting – ideal for cutting and bulking cycles.

3 Brain health

Cardarine can improve blood flow to the brain, protecting brain vessels, boosting the growth of nerve cells, and reducing problematic inflammation.

4 Training endurance

Cardarine stimulates your body’s use of glucose for fuel, which means you can probably train longer and harder. More training = more muscle gain!

5 Muscle growth

Cardarine activates the PPAR-delta which boosts muscle fibres, gives you increased energy and means you can train for longer too.

6 Heart health

Cardarine may have a protective benefit for your blood vessels, reducing oxidative damage and plaque build-up, and increasing your levels of nitric oxide.

How To Dose Cardarine

Cardarine is kind of an all-rounder, you can use it for cutting or bulking cycles. It has a half life of 16 hours, so you will need to split your daily total dose into two doses. Start with 10mg/day (5mg twice per day), ideally with one dose 2-3 hours before you train. Run Cardarine for a maximum of 12 weeks, followed by a 6 week off-cycle break.

Can You Stack Cardarine?

A Cardarine Review wouldn’t be complete without some stack suggestions, so here they are! GW can be stacked with most other compounds. It mitigates fat-gain during bulking cycles, increases fat-loss during cutting cycles, and enhances endurance and performance all-round. Here are the most popular SARMs stacks:

Body-Recomposition Stack

  • Cardarine GW-501516
  • Ligandrol LGD-4033
  • Andarine S-4

Cutting Stack

  • Testolone RAD-140
  • Cardarine GW-501516
  • Stenabolic SR-9009
  • Andarine S-4

Strength Stack

  • Testolone RAD-140
  • Cardarine GW-501516
  • Andarine S-4

Bridging Stack

  • Andarine S-4
  • Ostarine MK-2866
  • Cardarine GW-501516
  • Stenabolic SR-9009

Endurance Stack

  • Cardarine GW-501516
  • Stenabolic SR-9009

Bulking Stack (with minimum fat-gain)

  • Cardarine GW-501516
  • Ostarine MK-2866
  • Ligandrol LGD-4033
  • Testolone RAD-140

Does Cardarine Have Any Side-Effects?

Like any compound, you should be sensible about using Cardarine. This includes looking out for side effects. Cardarine won’t suppress your natural hormone levels. It is always recommended to start off with lower doses and assess response and adaptation. If there is anything we haven’t covered in this Cardarine Review, see our Guide to Cardarine for more information.

andarine s4 benefits dosages blog

Andarine S4: Benefits, Dosages (Complete Guide)

Andarine (also known as S4) is a powerful selective androgen receptor modulator which can support muscle growth, mass, and density. This article will tell you everything you need to know about this increasingly favourable compound.

What Is Andarine S4?

Andarine S4 is a SARM (a selective androgen receptor modulator) sometimes also known as SARM S4. Like many SARMs, it has positive benefits on muscle mass, muscle gain and anabolism (helping you build muscle tissue and minimise muscle loss). But Andarine is stronger and more potent than many other SARMs.

Different SARMs have different levels of potency and this shows up in the results you can expect (and in what timeframe). What you need to know about Andarine is that it is pretty strong as SARMs go – so you can expect measurable results in a short time frame.

But there are some side effects to watch out for and we’ll detail those further in this article. However, Andarine is selective in which receptors it binds too, so side effects should be minimal if you are healthy and stick to recommended dosages.

Andarine works by binding to androgen receptors (in muscle tissue and bone tissue) which encourages your body to grow muscle. As a by-product of this, you’ll get stronger in the gym, you’ll be able to lift more and recover faster which will lead to yet more muscle gain.

Andarine S4 has been through human trials but no studies were published. There is some limited information which suggests that S-4 was described as the ideal SARM due to its single-day dosing, complete oral bioavailability and significant anabolic effects.

Understand The Benefits Of Andarine S4

Andarine can be used for bulking, cutting, body recomposition, strength gains, or competition prep but please remember you can not use Andarine – or any SARM – if you compete in drug-tested sport, including tested bodybuilding competitions because SARMs are banned by WADA.

  1. Dense muscle tissue – Andarine is renowned for giving that hard, dry look to muscles (which is why bodybuilder like it). Ideal if you want a full, pumped look
  2. Fat loss – Andarine seems to help with fat loss, possibly because it increases the metabolism of body fat and suppresses HSL (hormone-sensitive lipase)
  3. Strength gains – Andarine helps you build strength, and you may notice significant strength gains within a few weeks
  4. Dry gains – you shouldn’t experience water retention with SARM S4, meaning your muscle gains will look dry, not watery
  5. High bioavailability – meaning Andarine is absorbed into your system quickly, so it gets to work rapidly, even at low doses

You can see why S-4 is popular with bodybuilders, powerlifters, and other strength and power athletes. Just be careful with tested competition – like we’ve said, Andarine is banned (as are all SARMs) by WADA.

Are There Any Side Effects Of Andarine S4?

You should stay open to the possibility of side effects with any compound or medicine. Andarine is no different. Remember, SARMs were originally developed as potential medical solutions to physical issues, and most drugs have some potential side effects.

So what are the side effects of Andarine, and how can you minimise the chance of them happening? There are two key side effects to be aware of:

  • Night vision disturbance – some people report a kind of yellow tinge to their vision at night (probably because SARM S4 binds to receptors in the eyes). This shouldn’t be a problem – unless you work shifts, or need to drive or operate any kind of machinery at night. Most of these reports come from people taking high doses of Andarine.
  • Testosterone suppression – S4 does impact your natural test levels, and you will need to do a PCT (post cycle therapy) after using Andarine. Another way to keep this risk to a minimum is to run short cycles of 8 weeks maximum.

How To Use Andarine, Best Dosages

The best way to minimise the risks of any side effects is to get informed about how to use Andarine. This includes how much (dosages), how often (should you split the dose), and for how long (cycle length).

Andarine is a strong SARM, which means you can see good results even at low doses, so there is no need to take high doses – in fact, this just opens you up to more risk of side effects, for no need.

  • Start with 20mg-25mg Andarine a day.
  • Split your dose (whatever dose you take) into 2-3 doses per day. Take a dose in the morning, and one with your pre-training meal. If you are taking 1/3 dose, do this 4 hours after your previous dose.
  • After 2 weeks, assess your progress and results
  • If your progress has slowed down or stopped, increase the dose by 5mg per week for the rest of your cycle.
  • Do not keep increasing the dose all the while you are getting results – only increase it if your results stop.
  • Never go higher than 50mg/day (in fact, 35mg/day is a high dose).
  • Never take Andarine S4 for longer than 8 weeks (6-8 weeks is the least risky).

Andarine vs Other Popular SARMs

S4 is sometimes stacked with Ostarine (for cutting). Ostarine can be beneficial for building muscle mass and body recomposition. Andarine can also be stacked with Cardarine (for strength training), or with Ligandrol (for bulking). Remember, Andarine is already a strong SARM so there is no real need to stack.

Andarine S4 is a powerful SARM which is a kind of all-rounder, helping build muscle mass, burn body fat, and boost strength. But remember it is banned by WADA and can not be used for any tested sport or competition.

3 Surprising Benefits of LGD-4033

3 Surprising Benefits of LGD-4033

In this article we’ll take a brief look at the 3 Surprising Benefits of LGD-4033 and if you want to know more, head over and read our blog post on Amazing Benefits of Ligandrol for more information. We’ll go over everything you need to know about this powerful SARM and its noteworthy benefits if you’re looking to transform your physique in just 8-12 weeks!

Ligandrol LGD-4033 is one of the most popular selective androgen receptor modulators (SARMs) on the market and its growing reputation isn’t to be taken lightly. This compound really helps you pack on muscle mass, develop denser muscle tissue, increase lifting strength and get leaner during a diet phase. Before you decide whether Ligandrol should be part of your supplement stack, read this and find out about the potential benefits of LGD-4033.

What Is Ligandrol LGD-4033?

Ligandrol LGD 4033 is a SARM – a selective androgen receptor modulator. It’s typically used by men and women who want to enhance their physique and build strength because it has been shown to have a positive impact on muscle building, training performance, fat loss potential and even bone strength.

Ligandrol binds to the body’s androgen receptors (in muscle and bone tissue), where it boosts anabolic activity and suppresses catabolism – which is how it can have an impact on growth and recovery.

All SARMs are selective to bone and muscle tissue, possibly because these tissues have more of the co-regulator sensors they need. Ligandrol does activate androgen receptors but it is chemically different from any kind of anabolic steroid.

How Was Ligandrol Developed?

Like most SARMs, Ligandrol was originally developed as a medical drug to combat troublesome health issues. Specifically, Ligandrol was developed to reduce muscle wastage in muscular dystrophy sufferers and to help people recover better from hip fractures.

Its impact on cell growth and tissue recovery was picked up by bodybuilders who recognised it as a potent compound for muscle gain. Ligandrol is still a relatively new compound so there is limited official scientific research into its effects but there’s plenty of anecdotal evidence from within the bodybuilding community.

Ligandrol is not restricted for human use but you need to know it is banned by WADA so you should steer clear of it (and of all SARMs) if you aim to compete in professional sports or in drug-tested bodybuilding or physique contests.

Ligandrol For Bodybuilding

Lingandrol is popular with bodybuilders training for hypertrophy (muscle gain), strength, mass and fat loss. But it is also a common choice of SARM for physique models, CrossFit athletes and regular gym-goers. The benefits of LGD-4033 offer a versatile compound for anyone who wants to take their physique to the next level and fast. LGD4033 will help you to pack on the muscle and diet for fat loss without the usual risk of catabolism and muscle loss.

3 Surprising Benefits Of LGD-4033

#1 Muscle gain

Ligandrol targets anabolic pathways in the body and has been shown in human clinical trials to increase muscle mass and leg strength. Aside from this study, there is plenty of anecdotal evidence from bodybuilders who use LGD-4033 (alone, or with other compounds) to boost muscle mass and density, plus strength and training performance.

#2 Strong bones

By activating the body’s androgen receptors, Ligandrol may increase bone density and strength. This is important for bodybuilders as strong bones mean a strong foundation on which you can create a great physique. In addition, healthy bones mean you can lift heavier without fear of excess injury risk. Every bodybuilder needs to think about skeletal strength.

#3 Cognitive health

Although SARMs work on muscle and bone tissue, there is some evidence to suggest Ligandrol directly affects the brain, too. This is of interest to bodybuilders because of cognitive health impacts on training focus, endurance and motivation.

Aside from these 3 Surprising Benefits of LGD-4033, bodybuilders report a lot of other benefits to using Ligandrol, including:

  • more visible muscle pumps during training
  • maintaining muscle gain (even after a cycle)
  • easier and faster fat loss when dieting
  • increased energy and endurance
  • a feeling of energy and focus during the day
  • faster recovery between training sessions
  • increased strength for weight training
  • mood-boosting for mental wellbeing

Dosage & Cycling

Bodybuilders use Ligandrol for bulking cycles, cutting cycles and for body recomposition (lean gains) periods of training. LGD4033 can be used by itself but it can also be stacked with other SARMs or different types of compounds. Common SARMs stacks include Ligandrol with Cardarine, Testolone (for strength and muscle gain) or Ostarine (for fat loss or body recomp). Check out Mutagenic Labz Symbiote capsules if you want a reliable blend of Ostarine MK-2866 and Ligandrol LGD-4033.

One study showed pretty impressive gains on a dose of just 1mg per day but most guys will run Ligandrol doses should be up to 10mg per day (for men), and up to 5mg per day for women. The half-life of Ligandrol is 24-36 so there is no need to split the dose (most people take their daily dose in one go).

Advice on length of cycles is mixed, with some people advising a 4-week limit (followed by a 4-week recovery period) but others use Ligandrol for 8 or even 12 weeks for fat loss. Most people don’t feel the need for PCT after a Ligandrol cycle as the suppression is very mild but a great way to boost recovery post-cycle is with the use of testosterone boosters to help stimulate natural hormone production levels after use.

We know from clinical trials that levels of blood LGD 4033 can almost triple after 3 weeks (compared to day 1) – this tells us that concentration of the compound does build up in the body. This might be one reason for shorter cycles.

Choosing The Best Ligandrol Product

Ligandrol might be banned in drug-tested sport but it’s available as a research chemical. However, you still need to be smart about where you get your SARMs.

There are a lot of disreputable sellers out there who either pack their products with weird extra ingredients or who can’t prove the quality and dosage of the active compound.

We recommend Mutagenic Labz Symbiote that offers a super-popular blend of Ligandrol with Ostarine. This is one of the best SARMs stacks for lean gains, body recomposition, or fat loss with muscle gain. Symbiote gives you 4mg Ligandrol with 10mg Ostarine.

If you want LGD4033 on its own, go for Research Pharma UK LGD-4033 Pro which contains an “Absorb Core” base to improve bioavailability and to extend the half-life of the compound, making it one of the strongest and most efficient on the Research Compound market.

If these 3 Surprising Benefits of LGD-4033 didn’t impress, head over to our blog post on Amazing Benefits of Ligandrol for more information

5 amazing benefits of ostarine mk-2866

5 Surprising Benefits of Ostarine MK-2866

Discover everything you need to know about the popular SARM Ostarine, also known as MK-2866. Ostarine is one of the most popular SARMs in the bodybuilding and physique world – no surprise once you learn about the potential effects of this research-backed compound.

What Is Ostarine?

If you’ve been around the bodybuilding or physique sport world for even a short while, you’ve probably heard about Ostarine. But what is this compound, why do some people use it, and should you consider it (or should you look for a better alternative)? To begin, it’s worth mentioning that this is widely considered one of the safest anabolic SARMs on the market.

MK-2866 is a SARM (Selective Androgen Receptor Modulator) which is popular with strength, power and physique athletes who are looking for ways to boost muscle mass and strength with fewer or no side effects compared to harsher compounds such as steroids or prohormones. It was originally developed to help treat muscle-wasting conditions, so you can understand why bodybuilders are drawn to it. It preserves lean tissue when conditions would usually lead to catabolism (for example, dieting or high-frequency training).

How Does MK-2866 Work?

Like any SARM, MK-2866 can mimic testosterone (the primary anabolic hormone), stimulates the body’s androgen receptors and boosts the steroid hormone receptors. It can activate stem cells, helping to regenerate and build muscle and bone tissue – exactly what bodybuilders want. For this reason, MK-2866 is thought to have fewer side-effects than anabolic steroids because SARMs do not affect the organs. They are very selective by their very nature, which is the main advantage of any SARM. Of course, this can change if someone stacks Ostarine with an anabolic steroid.

Ostarine is renowned for improving both training performance (strength and power) and physique appearance (through bigger, denser muscle mass). However, its noteworthy advantage is injury repair and recovery; it has an excellent affinity for joint repair in particular.

Muscle Gain & Recovery with MK-2866

One reason many bodybuilders use MK-2866 is for its impact on the IGF-1 gene, as well as muscle cells and cells in connective tissues. Ostarine may stimulate these cells which means faster recovery from training stress. Less time out for recovery (or less soreness during your next training session) means you can train more frequently, achieving a greater workload across the training week. This is likely to result in greater muscle growth from the training stimulus.

In one human study of 120 healthy elderly people, Ostarine significantly increased lean muscle mass as well as fitness levels with no side effects or steroid-like risks.

5 Potential Effects Of Ostarine

There are five key reasons a bodybuilder might choose to use Ostarine.

#1 Muscle gain
The SARM is often used as a compound to aid muscle gain because of its effect on stimulating muscle cells. Not only does this mean you may gain additional muscle tissue but you are likely to protect the muscle mass you already have (important during a fat loss phase).

#2 Recovery
It can mean faster recovery from DOMS and training fatigue. This means you can train more frequently and you can push harder during each session.

#3 Fat loss
It is thought to slow or stop muscle breakdown (catabolism) whilst the body is getting leaner. This means you can push harder during a dieting phase without the usual worry about losing muscle, resulting in the holy grail of lean gains.

#4 Cardiovascular health
Ostarine can have a number of benefits for heart health, including reduction of triglycerides, reduced lipids and reduced total cholesterol. It may also help lower blood glucose levels and improve insulin resistance.

#5 Increased metabolic rate
It is thought to increase base metabolic rate, meaning you will burn more calories during training, NEAT and cardio. It can also increase endurance and give you better stamina, which will also mean longer more intense training sessions. All these combined means you are likely to burn more calories – good news if you are trying to get shredded.

How Long Does MK-2866 Take to Work?

As with most supplements, one of the most commons questions asked is how long MK-2866 takes to work. Anecdotal evidence shows that people tend to feel a great sense of ‘wellbeing’ within 2-3 days of using Ostarine. A sense of vitality, positive mood, good energy and holistic ‘balance’.

Many bodybuilders and athletes report noticeable consistent strength gains within the first 2-3 weeks of using the compound. In terms of physical changes; body composition and muscle definition, results will usually be seen to the eye from 4 weeks onwards, however, it’s important to understand that this ultimately comes down to so many individual factors. Your current body composition, your goals, your training and diet, as well as recovery protocols. Everyone will respond to different compounds in different ways whilst your efforts and commitment will play an even bigger part in how quickly you see results.

Ostarine & Bodybuilding

MK-2866 is best known for is building muscle and burning fat – two things all bodybuilders are interested in at some point during their lifting career (even if they never want to step on stage).

Muscle gain: remember how we said Ostarine was originally developed to help tackle muscle wasting diseases? People who want to build more muscle tissue, and hang on to the muscle they’ve got, can use MK-2866 to harness those anti-catabolic effects.

Fat burning: Ostarine has muscle preserving properties, meaning you can diet more aggressively or for longer without losing muscle tissue. Retaining muscle during a diet phase means you’ll also retain more strength, so you can train harder and heavier, all leading to a positive circle of lean gains.

But there’s more than muscle building and boosted fat-burning abilities. Ostarine can also boost bone health, help reduce LDL and triglycerides and improve insulin resistance. These are all things which can be attractive to bodybuilders looking to gain mass and strength.

How to Stack Ostarine

Bodybuilders use Ostarine in a few different ways. This is what you need to know.

Using Ostrarine by itself: Ostarine MK-2866 can be used alone. It should be used as a cycle (like any SARM) of 12 weeks for men, up to 8 weeks for women. Men should use between 15-25mg and women should use 5-10mg. Ostarine has a half-life of 24 hours so there is no need to split the dose across the day.

With other SARMs: bodybuilders typically stack Ostarine with other popular SARMs, like Ibutamoren MK677 or Ligandrol LGD-4033. Ostarine can also be used in a so-called “triple SARM” stack of Ostarine plus Andarine and Cardarine (although Cardarine isn’t a true SARM).

Choose The Best Ostarine Supplement

Like any SARM, it’s important you choose the best-quality Ostarine MK-2866 supplement. Don’t go for the cheapest product. Check the label carefully and look for smart ingredients which are designed to optimise the product’s effectiveness so you see the best gains.

We love our best selling Mutagenic Labz Ostagainz, which delivers 10mg of pure Ostarine MK-2866 along with Piperine in every dose (to aid digestion and absorption). It’s non-liver-toxic, has no androgenic activity, and promises minimal side effects – with maximum results. Click here to try it for yourself. Choose an Ostarine product you can trust, backed by a reliable name in bodybuilding supplements.

We should point out that Ostarine – like all SARMs – is not approved for use in tested strength and physique sports but for those of you who don’t want to compete with the tested federations? There are so many reasons to try Ostarine by itself or as a stack, whether you’re dieting, bulking, or aiming for a body recomposition phase.

Cardarine GW-501516: A Complete Guide to GW501516

Cardarine GW-501516: A Helpful Guide 2019

In this article, we’ll cover everything you need to know about the PPAR-delta activator Cardarine (GW-501516), how long it takes to work, the ideal cycle length, safety and vital information you need before you consider adding it to your supplement regime.

A lot of the compounds we write about at PumpingIron.com are SARMs (selective androgen receptor modulators). This article is about something a little different, although often classed into the same category. GW501516 can help burn fat, boost metabolism, increase training endurance and protect muscle tissue but it isn’t actually a SARM. It’s a non-hormonal PPAR-delta activator which doesn’t work on the androgen capacitors at all.

If you’re curious about Cardarine, here’s everything you need to know and if we haven’t covered something, simply e-mail us and we’ll be happy to answer your questions!

Is Cardarine (GW-501516) a SARM?

As we said, Cardarine isn’t actually a SARM (anyone who tells you it is doesn’t know what they’re talking about). A SARM activates androgen receptors in muscles and other tissue. Cardarine is a PPAR-delta activator but it can produce results similar to those of SARMs.

Background Information

The best way to understand what to expect from a compound is to look at why it was developed (and what was discovered by researchers). GW501516 was originally developed by a drug company in the 1990s as a way to prevent tumours (especially on the colon and prostate). But there were some surprising discoveries.

During their studies into increased endurance and fat burning, the researchers began to understand more about the PPAR-delta pathway. They realised that activation of this pathway had an astounding impact on muscle growth, endurance and energy whilst decreasing blood lipids and subcutaneous fat. And – you guessed it – the compound GW-501516 can bind to this PPAR-delta pathway.

It turned out Cardarine could help reduce body fat, boost metabolic rate, improve the strength of blood vessels. This has a positive impact on cardiovascular health, increases muscle growth rate and even reduces recovery time. We’ll go into these factors in greater depth later in this article.

One thing we need to make clear: Cardarine is not currently sold for human consumption. It is classed as a ‘research compound’, sold for research purposes only.

How Long Does Cardarine Take to Work?

It’s important to understand how the Cardarine works in the body. Like we’ve already said, it binds to PPAR-delta in muscle cells and it stimulates certain genes which facilitate the body’s use of energy. Once you know that, you can see how it can boost your metabolic rate, improve physical performance and even help burn more fat (whilst increasing and protecting muscle mass).

You’ll notice the effects almost instantly; timing one of your dosages about thirty minutes before a high-intensity training session is an ideal protocol. The difference in energy, endurance and stamina will be noticeable almost immediately.

Burn Fat & Recover Faster with GW-501516

How exactly does Cardarine burn body fat? It’s not as simple as just torching fat right off your body. It starts with preventing the formation of fatty acids chains which, in turn, stops your body actually storing fat. This means your body needs to tap into your subcutaneous fat stores for energy – just like when you diet. But there’s one big difference to when you burn body fat by dieting. GW-501516 has those sought-after anti-catabolic properties, which means you get leaner without losing valuable muscle tissue.

What about boosting recovery between training sessions? It seems Cardarine can help your muscle fibres (specifically the slow-twitch fibres) use oxygen more efficiently, and this can help improve rates of recovery between training. It can also mean better endurance during training sessions. Good news if you train for hypertrophy, with a lower-load and higher-rep style of training.

Cardarine & Bodybuilding

You can already guess that this is an attractive compound for bodybuilders with its potential for muscle gain, training recovery and fat burning. (Side note: it’s also getting a lot of interest with the nootropics crowd.)

Cardarine could be used by itself or with other compounds as a cycle; you can stack it with prohormones, SARMs or other fat-burners. You can also use it to bridge between cycles or throughout a PCT (post cycle therapy) phase. Either way, it should be cycled for best results. Plan your cycle length for 8-12 weeks before having a 4-8 week break.

GW501516 has a half-life of 12-24 hours so you can decide whether to split your dose or to take it once per day. A dosage of 10mg-20mg per day is recommended.

Stacking Cardarine with Other Compounds

Cardarine can be used as a standalone supplement but is often stacked with other compounds. Most commonly, it has great synergistic effects with MK-677, RAD-140, Ostarine, LGD-3303 and Andarine.

It can also be used to combat negative side-effects of some anabolics (such as Trenbolone) and address potential lipid health issues. Cardarine is beneficial during PCT because it can lessen your chances of a fat-regain or rebound after running a steroid or prohormone cycle.

7 Things You Need To Know About Cardarine

#1 Fat Burner

It boosts your body’s fat-burning capacity by stimulating glucose and activating the ABCA1 and CPT1 fat-burning genes. Interestingly, there was a human study done on Cardarine’s potential for receding fatty acids, VLDL proteins and triglycerides (human studies on Cardarine are pretty rare, so it’s worth a look at this one).

#2 Training Endurance

It can stimulate the body’s glucose uptake, encouraging your body to use glucose as its primary fuel source. This means you get more energised for training and can train harder for longer. Since Cardarine can activate PPAR-delta pathways, it can also improve strength endurance. This 2015 study (on mice) suggests Cardarine can increase the specific muscle fibres associated with peak training performance.

#3 Lean Gains

It is a popular choice for stacking with SARMs and other compounds to protect lean muscle tissue whilst dieting to get shredded. As we’ve said, it can help burn body fat without the problem of losing muscle mass or looking over-dieted and scrawny.

#4 Brain Health

It can have a positive effect on blood vessels (see #5) and this means protection for your brain blood vessels (plus more blood to the brain). You might also like to know PPAR activators are thought to boost nerve cell development of nerve cells.

#5 Cardiovascular Health

It can prevent oxidative damage to blood vessels, helping reduce build-up in the arteries and (most exciting for bodybuilders) increasing your nitric oxide (NO) levels. This could mean Cardarine may reduce inflammation and associated tissue damage – a key factor in recovery and muscle growth during hypertrophy.

#6 Liver & Kidney Health

MCP-1 activity is a key factor in kidney disease and Cardarine can reduce this activity. Additionally, Cardarine acts directly on your liver (a powerhouse for storing fats for fuel in the body), using PPAR-delta activation to use fatty acids for energy. Cardarine could even reduce the body’s production of IL-6 and thereby prohibit insulin resistance.

#7 Muscle fibres

Activating PPAR-delta also means Cardarine can encourage better muscle fibre development. This means increased training endurance and the potential for greater muscle growth.

Choosing & Using Cardarine GW-501516

The bottom line is that Cardarine GW501516 is not currently legal for human consumption so it is sold for research purposes. Not for training, cutting, bulking, or bodybuilding.

You also need to bear in mind that Cardarine is banned for any tested bodybuilding competitions (yes, even trace amounts found accidentally in another product). At the moment, almost all the (limited) research on Cardarine GW501516 is on animals.

Don’t risk wasting your money on cheap, fake dupes!

One of the best selling products Mutagenic Labz Amalgamation combines a blend of GW-501516 and SR-9009, a very effective fat-loss combo. If you’re not keen on Cardarine just yet, Check out Mutagenic Labz Assimilation – our safe, legal and insanely effective GDA (Glucose Disposal Agent) to help you get leaner and build more muscle faster.

Disclaimer: By publishing this post we are not recommending using GW501516. It’s our duty to inform and educate you on all compounds. All of the information we have given here can be corroborated by published scientific reviews and literature. We recommend Mutagenic Labz Assimilation.

Dry Gains with M-Sten (25lbs in 4 Weeks)

Insane Dry Gains with M-Sten (25lbs in 4 Weeks)

If you’ve taken an interest in prohormones, there’s no doubt you’ve heard about M-Sten, or Methyl Sten, short for Methylstenbolone, which was first brought to the market as Ultradrol.

Methystenbolone is one of the strongest prohormones on the market which makes it one of the most popular bulking compounds in the prohormone category. Where M-Sten stands out from the rest is the quality of lean muscle gain; its advantage is very little water retention, greater vascularity and definition.

Another advantage of M-Sten is that it doesn’t convert to estrogen. That means no problems “down below”, either with performance or bladder.

Methylstenbolone is banned by WADA so is not recommended for drug-tested athletes.

What are the Benefits of Methylstenbolone?

Gains of an M-Sten cycle are impressive, with a reported lean mass gain of up to 25 lbs in 4 weeks. What you can expect from an M-Sten cycle:

  • Dry gains – minimal water retention
  • Doesn’t convert to estrogen
  • Boosts strength levels
  • Helps promote the development of fuller muscles
  • Considerable size and mass gains
  • Allows you to train longer and harder, which means you get results quicker
  • There are quite a few reports about 3% body fat reduction while gaining as much as 6 pounds of muscle in a 4-week cycle

How to Cycle M-Sten

Gearing up for lean muscle gain means you need to eat more and better than usual; your diet should be on point for best results. Drink lots of water – M-Sten is not liver-friendly. For the same reason, avoid alcohol, that’s the last thing your liver needs on a prohormone cycle. Do it right and you’ll be seeing results in the first couple of weeks.

We recommend 4 weeks on M-Sten initially, and no more than 6 for experienced users.

Depending on your goals, you can adapt your dosages – for cutting, lower dosages work perfectly, whereas for bulking, tapering up the dosage will optimise results. Here are a few protocols you might want to consider:

Newbie Users: 4-week cycle (Week 1-2, 1 capsule per day
, Week 3-4, 2 capsules per day)

Experienced Users: 4-week cycle (Week 1, 1 capsule per day
, Week 2-4, 2 capsules per day)

Advanced Users: 4-week cycle (
Week 1, 1 capsule per day
, Week 2-3, 2 capsules per day
, Week 4, 3 capsules per day)

Do I need to run PCT after a Methylstenbolone Cycle?

Yes. It’s not just your cycle that matters; your Post Cycle Therapy is the phase that makes all the difference. Having a solid PCT protocol will ensure you keep your gains, restore your testosterone levels, balance your hormones and ensure you don’t suffer from those ‘post-cycle blues’. Run your PCT for 4 weeks – we recommend the Mutagenic Labz Regen-T (Total PCT).

Another little-known secret to the perfect PCT is bridging your prohormone cycle with SARMs.

Signs that show you need to pay more attention to your PCT:

  • Feeling tired when you normally wouldn’t
  • Being more aggressive and not knowing why
  • Lower sex drive
  • Back pumps (taurine can help)
  • Joint pain

What are the Side Effects of M-Sten?

It’s not all good news though, but you knew that, right? M-Sten is pretty toxic, to avoid liver damage you’re going to need a quality liver support such as Mutagenic Labz TUDCA Plus.

M-Sten can affect your kidneys too; if you get dark urine while you’re using, that’ll be down to elements that aren’t being metabolized by your body.

M-Sten can also affect your blood pressure and cholesterol, so maintaining a good diet is critical.

Although it doesn’t convert to estrogen, any prohormone will mess with your hormone levels, which means estrogen could be produced because of other factors.

Stacking M-Sten

The Mutagenic Labz Hulk Stack includes M-Sten, Assimilation and Metamorphosiz.

  • Ideal for: Lean Bulking, Cutting/Shredding, Strength, Endurance, Fullness, Huge Pumps, Vascularity, Lean Mass Gain
  • No Bloating or water retention
  • Does not aromatise
  • Highly anabolic
  • Cycle protocol: 4 weeks (8 weeks off)
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